Deficits in sensory gating are believed to be involved in a variety of clinical symptoms and disrupted cognitive functions in patients with schizophrenia. The psychological and biological mechanisms of normal and impaired gating, and why some novel antipsychotic medications improve gating while conventional antipsychotics do not, are not well understood. Progress toward understanding neural mechanisms involved in gating can contribute to theory about schizophrenia and to its treatment. A prominent research paradigm for studying gating deficits in schizophrenia involves presentation of a pair of clicks and noninvasive measurement of the P50 component of the associated event-related brain potential. P50 amplitude to the second click is normally reduced substantially from that to the first click, but patients (and some of their family members) commonly show less reduction, i.e. have impaired gating. The proposed project will address three pressing issues surrounding this well-established finding. (1) What are the neural generators of P50? Are they confined to bilateral superior temporal gyrus? (2) How are those generators affected by antipsychotic medication, is the effect equal across the generators, and is the effect different for conventional vs. novel antipsychotics? (3) Is the gating deficit specific to auditory stimuli, or is it cross modal as the literature assumes? This application presents extensive pilot data addressing all three of these issues in hopes of furthering our understanding of impaired sensory gating in schizophrenia.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Research Project (R01)
Project #
1R01MH065304-01
Application #
6460533
Study Section
Special Emphasis Panel (ZRG1-BBBP-5 (01))
Project Start
2002-08-05
Project End
2007-07-31
Budget Start
2002-08-05
Budget End
2003-07-31
Support Year
1
Fiscal Year
2002
Total Cost
$277,331
Indirect Cost
Name
Biomedical Research Institute of New Mex
Department
Type
DUNS #
807430764
City
Albuquerque
State
NM
Country
United States
Zip Code
87108
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Edgar, J Christopher; Fisk IV, Charles L; Chen, Yu-Han et al. (2017) By our bootstraps: Comparing methods for measuring auditory 40 Hz steady-state neural activity. Psychophysiology 54:1110-1127
Chen, Yu-Han; Stone-Howell, Breannan; Edgar, J Christopher et al. (2016) Frontal slow-wave activity as a predictor of negative symptoms, cognition and functional capacity in schizophrenia. Br J Psychiatry 208:160-7
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Huang, Ming-Xiong; Huang, Charles W; Robb, Ashley et al. (2014) MEG source imaging method using fast L1 minimum-norm and its applications to signals with brain noise and human resting-state source amplitude images. Neuroimage 84:585-604
Edgar, J Christopher; Chen, Yu-Han; Lanza, Matthew et al. (2014) Cortical thickness as a contributor to abnormal oscillations in schizophrenia? Neuroimage Clin 4:122-9
Edgar, J Christopher; Hunter, Michael A; Huang, Mingxiong et al. (2012) Temporal and frontal cortical thickness associations with M100 auditory activity and attention in healthy controls and individuals with schizophrenia. Schizophr Res 140:250-7
Hunter, Michael; Villarreal, Gerardo; McHaffie, Greg R et al. (2011) Lateralized abnormalities in auditory M50 sensory gating and cortical thickness of the superior temporal gyrus in post-traumatic stress disorder: preliminary results. Psychiatry Res 191:138-44
Smith, Ashley K; Edgar, J Christopher; Huang, Mingxiong et al. (2010) Cognitive abilities and 50- and 100-msec paired-click processes in schizophrenia. Am J Psychiatry 167:1264-75
Euler, Matthew; Thoma, Robert J; Gangestad, Steven W et al. (2009) The impact of developmental instability on Voxel-Based Morphometry analyses of neuroanatomical abnormalities in schizophrenia. Schizophr Res 115:1-7

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