Abstract

Public Health Relevance

Adolescence, young adulthood and attention-deficit hyperactivity disorder (ADHD) are developmental periods and a condition associated with impulsivity and risk taking that lead to major public health problems in the form of greater self-harm, substance use disorders, higher accident rates and lower educational and occupational outcomes. This longitudinal study in teens and young adults (15-30 years of age) will identify how and when different brain processes work together toward reductions in impulsivity using a combination of brain imaging methods, behavioral measures and rating scales to look at important real world outcomes (e.g., academic and occupational success, drug use, mental health symptoms, accident rates). The long-term goals of the project are to: 1) inform our understanding of development during this critical period and 2) identify those who are at-risk due to impulsive decision-making to inform targeted prevention and intervention strategies to reduce impulsivity and improve long-term outcomes for those at-risk for harm related to their impulsive behavior.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Research Project (R01)
Project #
3R01MH091068-08S1
Application #
10129580
Study Section
Neural Basis of Psychopathology, Addictions and Sleep Disorders Study Section (NPAS)
Program Officer
Pacheco, Jenni
Project Start
2012-08-15
Project End
2022-05-31
Budget Start
2020-08-20
Budget End
2021-05-31
Support Year
8
Fiscal Year
2020
Total Cost
Indirect Cost

  Institution

Name
University of California Davis
Department
Psychiatry
Type
Schools of Medicine
DUNS #
047120084
City
Davis
State
CA
Country
United States
Zip Code
95618

  Publications

Fassbender, Catherine; Mukherjee, Prerona; Schweitzer, Julie B (2017) Minimizing noise in pediatric task-based functional MRI; Adolescents with developmental disabilities and typical development. Neuroimage 149:338-347
Brahmbhatt, Khyati; Hilty, Donald M; Hah, Mina et al. (2016) Diagnosis and Treatment of Attention Deficit Hyperactivity Disorder During Adolescence in the Primary Care Setting: A Concise Review. J Adolesc Health 59:135-43
Aranovich, Gabriel J; McClure, Samuel M; Fryer, Susanna et al. (2016) The effect of cognitive challenge on delay discounting. Neuroimage 124:733-739
Cavagnaro, Daniel R; Aranovich, Gabriel J; McClure, Samuel M et al. (2016) On the Functional Form of Temporal Discounting: An Optimized Adaptive Test. J Risk Uncertain 52:233-254
Guyer, Amanda E; Silk, Jennifer S; Nelson, Eric E (2016) The neurobiology of the emotional adolescent: From the inside out. Neurosci Biobehav Rev 70:74-85
Hartanto, T A; Krafft, C E; Iosif, A M et al. (2016) A trial-by-trial analysis reveals more intense physical activity is associated with better cognitive control performance in attention-deficit/hyperactivity disorder. Child Neuropsychol 22:618-26
Besemer, Sytske; Loeber, Rolf; Hinshaw, Stephen P et al. (2016) Bidirectional Associations Between Externalizing Behavior Problems and Maladaptive Parenting Within Parent-Son Dyads Across Childhood. J Abnorm Child Psychol 44:1387-98
Rodriguez, Christian A; Turner, Brandon M; Van Zandt, Trisha et al. (2015) The neural basis of value accumulation in intertemporal choice. Eur J Neurosci 42:2179-89
Schweitzer, Julie B; Riggins, Tracy; Liang, Xia et al. (2015) Prenatal drug exposure to illicit drugs alters working memory-related brain activity and underlying network properties in adolescence. Neurotoxicol Teratol 48:69-77
Romens, Sarah E; Casement, Melynda D; McAloon, Rose et al. (2015) Adolescent girls' neural response to reward mediates the relation between childhood financial disadvantage and depression. J Child Psychol Psychiatry 56:1177-84

Showing the most recent 10 out of 28 publications