Abstract

Various affects of postnatal undernutrition are being investigated using developing rats as an experimental model. Studies are largely confined to the central nervous system. Neurochemical investigations include effects on synthesis of myelin as well as on the development of neurotransmitter receptor binding systems. Morphological studies include the cellular basis of nutrition related hypomyelination. Neurophysiologic correlates include effects of undernutrition on maturation of the photic evoked responses in the retina (electroretinogram), the optic tract, lateral geniculate bodies, and the visul cortes.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Project (R01)
Project #
5R01NS013799-10
Application #
3395328
Study Section
Neurological Sciences Subcommittee 1 (NLS)
Project Start
1989-01-01
Project End
1993-06-30
Budget Start
1990-07-01
Budget End
1991-06-30
Support Year
10
Fiscal Year
1990
Total Cost
Indirect Cost

  Institution

Name
West Virginia University
Department
Type
Schools of Dentistry
DUNS #
191510239
City
Morgantown
State
WV
Country
United States
Zip Code
26506

  Publications

Gu, J; Royland, J E; Wiggins, R C et al. (1997) Selenium is required for normal upregulation of myelin genes in differentiating oligodendrocytes. J Neurosci Res 47:626-35
Zhu, W; Wiggins, R C; Konat, G W (1994) Glucocorticoid-induced upregulation of proteolipid protein and myelin-associated glycoprotein genes in C6 cells. J Neurosci Res 37:208-12
Ye, P; Laszkiewicz, I; Wiggins, R C et al. (1994) Transcriptional regulation of myelin associated glycoprotein gene expression by cyclic AMP. J Neurosci Res 37:683-90
Grubinska, B; Laszkiewicz, I; Royland, J et al. (1994) Differentiation-specific demethylation of myelin associated glycoprotein gene in cultured oligodendrocytes. J Neurosci Res 39:233-42
Yassini, P R; Wiggins, R C; Konat, G W (1993) Spatiotemporal expression of SCIP and myelin genes in rat brain during early postnatal development. Dev Neurosci 15:128-32
Royland, J E; Konat, G W; Wiggins, R C (1993) Myelin gene activation: a glucose sensitive critical period in development. J Neurosci Res 36:399-404
Royland, J E; Konat, G; Wiggins, R C (1993) Abnormal upregulation of myelin genes underlies the critical period of myelination in undernourished developing rat brain. Brain Res 607:113-6
Gu, J; Yassini, P; Goldberg, G et al. (1993) Cocaine cytotoxicity in serum-free environment: C6 glioma cell culture. Neurotoxicology 14:19-22
Wiggins, R C (1992) Pharmacokinetics of cocaine in pregnancy and effects on fetal maturation. Clin Pharmacokinet 22:85-93
Zhu, W; Kanoh, M; Ye, P et al. (1992) Retinoic acid-regulated expression of proteolipid protein and myelin-associated glycoprotein genes in C6 glioma cells. J Neurosci Res 31:745-50

Showing the most recent 10 out of 29 publications