Abstract

The long-term objective is to describe quantitatively the changes that occur in the response properties of central gustatory neurons as amino acid taste information is relayed from peripheral nerves through to brainstem and forebrain taste nuclei.
The specific aims are to determine the response properties of single peripheral, medullary and pontine taste neurons and to determine the nature and extent of interaction between taste and tactile input at the different synaptic levels of organization. Extracellular, electrophysiological unit recordings will determine whether different """"""""types"""""""" of amino acid responsive taste fibers exist and whether their response properties are modified in the brainstem. An estimation of the relative extent of bimodality (taste and tactile responsiveness) at each synaptic level will be determined. In addition, possible convergence between """"""""odor"""""""" (olfactory and/or nasal trigeminal) and taste pathways will be investigated. Also, a study of the response properties of the recently identified telencephalic taste area of the catfish will be initiated to provide initial information on forebrain processing of amino acid taste information. Statistical analyses of the response data, histological marking of recording sites and neuronal tracing studies with horseradish peroxidase (HRP) will all provide useful information for an accurate interpretation of the experimental results.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Project (R01)
Project #
2R01NS014819-06
Application #
3395769
Study Section
Communication Sciences and Disorders (CMS)
Project Start
1979-01-01
Project End
1988-08-31
Budget Start
1985-09-09
Budget End
1986-08-31
Support Year
6
Fiscal Year
1985
Total Cost
Indirect Cost

  Institution

Name
Louisiana State University A&M Col Baton Rouge
Department
Type
Schools of Arts and Sciences
DUNS #
075050765
City
Baton Rouge
State
LA
Country
United States
Zip Code
70803

  Publications

Lamb, C F; Caprio, J (1993) Diencephalic gustatory connections in the channel catfish. J Comp Neurol 337:400-18
Lamb, C F; Caprio, J (1993) Taste and tactile responsiveness of neurons in the posterior diencephalon of the channel catfish. J Comp Neurol 337:419-30
Lamb, C F; Caprio, J (1992) Convergence of oral and extraoral information in the superior secondary gustatory nucleus of the channel catfish. Brain Res 588:201-11
Michel, W; Caprio, J (1991) Responses of single facial taste fibers in the sea catfish, Arius felis, to amino acids. J Neurophysiol 66:247-60
Wegert, S; Caprio, J (1991) Receptor sites for amino acids in the facial taste system of the channel catfish. J Comp Physiol A 168:201-11
Hayama, T; Caprio, J (1990) Somatotopical organization of the intermediate nucleus of the facial lobe in the channel catfish, Ictalurus punctatus. Brain Res 516:137-40
Hayama, T; Caprio, J (1989) Lobule structure and somatotopic organization of the medullary facial lobe in the channel catfish Ictalurus punctatus. J Comp Neurol 285:9-17
Caprio, J; Dudek, J; Robinson 2nd, J J (1989) Electro-olfactogram and multiunit olfactory receptor responses to binary and trinary mixtures of amino acids in the channel catfish, Ictalurus punctatus. J Gen Physiol 93:245-62
Kanwal, J S; Finger, T E; Caprio, J (1988) Forebrain connections of the gustatory system in ictalurid catfishes. J Comp Neurol 278:353-76
Kanwal, J S; Caprio, J (1988) Overlapping taste and tactile maps of the oropharynx in the vagal lobe of the channel catfish, Ictalurus punctatus. J Neurobiol 19:211-22

Showing the most recent 10 out of 15 publications