The goal of this program is a physiological and anatomical analysis of the central neural mechanisms participating in circadian rhythm regulation. Circadian rhythms are an ubiquitous feature of organisms and in mammals, they appear to be genetically determined functions of endogenously generated oscillatory mechanisms. A number of these functions have profound effects on behavior and neuroendocrine regulation in the CNS. Previous studies have shown that the probable site of the """"""""master clock"""""""" for circadian rhythm regulation in mammals resides in the suprachiasmatic nucleus in the hypothalamus. Visual input directly from the retina and indirectly from other visual centers are involved in synchronization of circadian rhythms. Very little is known as to the precise areas of the suprachiasmatic nucleus involved, the mechanisms involved, the interaction of secondary and primary synchronizers and oscillators involved and the anatomical connections necessary for the generation of circadian rhythms. The physiological studies proposed here include chronic multiple unit recordings in the suprachiasmatic nucleus and surrounding areas of the hypothalamus of the awake rat. Anatomical studies are on the afferent and efferent connections of the suprachiasmatic nucleus. These studies are designed in order to determine the precise nature and some basic mechanisms of circadian rhythm generation in the mammal. The anatomical studies will elucidate the differential connections of the areas invloved in primary (and secondary) oscillation.

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Project (R01)
Project #
5R01NS015321-06
Application #
3396141
Study Section
Neurological Sciences Subcommittee 1 (NLS)
Project Start
1979-12-01
Project End
1985-11-30
Budget Start
1984-12-01
Budget End
1985-11-30
Support Year
6
Fiscal Year
1985
Total Cost
Indirect Cost
Name
University of California Irvine
Department
Type
Schools of Medicine
DUNS #
161202122
City
Irvine
State
CA
Country
United States
Zip Code
92697
Fallon, J; Reid, S; Kinyamu, R et al. (2000) In vivo induction of massive proliferation, directed migration, and differentiation of neural cells in the adult mammalian brain. Proc Natl Acad Sci U S A 97:14686-91
Solbrig, M V; Koob, G F; Fallon, J H et al. (1996) Prefrontal cortex dysfunction in Borna disease virus (BDV)--infected rats. Biol Psychiatry 40:629-36
Solbrig, M V; Koob, G F; Fallon, J H et al. (1994) Tardive dyskinetic syndrome in rats infected with Borna disease virus. Neurobiol Dis 1:111-9
Back, S A; Colon, M; Fallon, J H et al. (1993) Ventral mesencephalic and cortical transplants into the rat striatum display enhanced activity for neutral endopeptidase 24.11 ('enkephalinase';CALLA). Brain Res 612:85-95
Giolli, R A; Torigoe, Y; Clarke, R J et al. (1992) GABAergic and non-GABAergic projections of accessory optic nuclei, including the visual tegmental relay zone, to the nucleus of the optic tract and dorsal terminal accessory optic nucleus in rat. J Comp Neurol 319:349-58
Fallon, J H; Di Salvo, J; Loughlin, S E et al. (1992) Localization of acidic fibroblast growth factor within the mouse brain using biochemical and immunocytochemical techniques. Growth Factors 6:139-57
Ciofi, P; Fallon, J H; Croix, D et al. (1991) Expression of neuropeptide Y precursor-immunoreactivity in the hypothalamic dopaminergic tubero-infundibular system during lactation in rodents. Endocrinology 128:823-34
Christmas, P; Callaway, J; Fallon, J et al. (1991) Selective secretion of annexin 1, a protein without a signal sequence, by the human prostate gland. J Biol Chem 266:2499-507
Giolli, R A; Blanks, R H; Torigoe, Y et al. (1990) Opioid receptors in the accessory optic system of the rat: effects of monocular enucleation. Vis Neurosci 5:497-506
Fallon, J H; Annis, C M; Gentry, L E et al. (1990) Localization of cells containing transforming growth factor-alpha precursor immunoreactivity in the basal ganglia of the adult rat brain. Growth Factors 2:241-50

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