The long term objectives of the proposed research are to elucidate the roles of the forebrain in the control of effector systems in the central nervous system of mammals. Chemically-defined pathways originating in the forebrain and terminating in neuroendocrine, autonomic and classical motor areas will be studied with combined morphological and immunohistochemical techniques. Twelve groups of experiments are designed to address three specific aims. The first specific aim addresses the hypothesis that the forebrain extrapyramidal motor systems control the neuroendocrine, autonomic and classical motor systems, in part, through the mesopontine tegmentum. Combined retrograde and anterograde tracing techniques are applied at the light and electron microscopic levels to determine if neurons in the mesopontine tegmentum which project to the hypothalamus, brainstem and spinal cord receive input from pallidal and peripallidal neurons of the forebrain motor and limbic systems. The second specific aim addresses the hypothesis that the mesopontine tegmental area which receives convergent forebrain inputs contains separate sets of transmitter-specific neurons which have stereospecific projections to neuroendocrine, autonomic, and classical motor areas. Multiple labeling immunohistochemical techniques are combined with retrograde tracing techniques to determine the neurochemical content and axon collateralization patterns of mesopontine projections to the hypothalamus, brainstem and spinal cord. The third specific aim addresses the hypothesis that the traditional hypophysiotrophic zones contain two functional types of neurons: one which controls the pituitary and a second which projects back to higher forebrain areas. Combined tract tracing and immunocytochemical techniques used at the light and electron microscopic levels will be used to determine both the chemistry and connections of different sets of defined hypothalamic neuronal systems. The proposed studies will enhance our understanding of the higher neuronal control of motor systems and will provide new information on how the forebrain, brainstem and hypothalamus integrate diverse motor systems in humans.

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Project (R01)
Project #
2R01NS015321-10
Application #
3396140
Study Section
Neurological Sciences Subcommittee 1 (NLS)
Project Start
1979-12-01
Project End
1994-01-31
Budget Start
1989-02-01
Budget End
1990-01-31
Support Year
10
Fiscal Year
1989
Total Cost
Indirect Cost
Name
University of California Irvine
Department
Type
Schools of Medicine
DUNS #
161202122
City
Irvine
State
CA
Country
United States
Zip Code
92697
Fallon, J; Reid, S; Kinyamu, R et al. (2000) In vivo induction of massive proliferation, directed migration, and differentiation of neural cells in the adult mammalian brain. Proc Natl Acad Sci U S A 97:14686-91
Solbrig, M V; Koob, G F; Fallon, J H et al. (1996) Prefrontal cortex dysfunction in Borna disease virus (BDV)--infected rats. Biol Psychiatry 40:629-36
Solbrig, M V; Koob, G F; Fallon, J H et al. (1994) Tardive dyskinetic syndrome in rats infected with Borna disease virus. Neurobiol Dis 1:111-9
Back, S A; Colon, M; Fallon, J H et al. (1993) Ventral mesencephalic and cortical transplants into the rat striatum display enhanced activity for neutral endopeptidase 24.11 ('enkephalinase';CALLA). Brain Res 612:85-95
Giolli, R A; Torigoe, Y; Clarke, R J et al. (1992) GABAergic and non-GABAergic projections of accessory optic nuclei, including the visual tegmental relay zone, to the nucleus of the optic tract and dorsal terminal accessory optic nucleus in rat. J Comp Neurol 319:349-58
Fallon, J H; Di Salvo, J; Loughlin, S E et al. (1992) Localization of acidic fibroblast growth factor within the mouse brain using biochemical and immunocytochemical techniques. Growth Factors 6:139-57
Ciofi, P; Fallon, J H; Croix, D et al. (1991) Expression of neuropeptide Y precursor-immunoreactivity in the hypothalamic dopaminergic tubero-infundibular system during lactation in rodents. Endocrinology 128:823-34
Christmas, P; Callaway, J; Fallon, J et al. (1991) Selective secretion of annexin 1, a protein without a signal sequence, by the human prostate gland. J Biol Chem 266:2499-507
Giolli, R A; Blanks, R H; Torigoe, Y et al. (1990) Opioid receptors in the accessory optic system of the rat: effects of monocular enucleation. Vis Neurosci 5:497-506
Fallon, J H; Annis, C M; Gentry, L E et al. (1990) Localization of cells containing transforming growth factor-alpha precursor immunoreactivity in the basal ganglia of the adult rat brain. Growth Factors 2:241-50

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