Abstract

The present proposal is designed to quantify axonal sprouting in the dorsal root and tract of Lissauer in the rat. After sprouting is quantified, the effects of age on sprouting will be determined. Rats are the experimental animal and the operative paradigms are the surviving root of Liu and Chambers and the chronic hemisection. Axons will be counted in the electron microscope which has the resolution necessary for both myelinated and unmyelinated fibers.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Project (R01)
Project #
2R01NS017039-04A1
Application #
3397303
Study Section
Neurology B Subcommittee 1 (NEUB)
Project Start
1981-09-15
Project End
1988-03-31
Budget Start
1985-04-01
Budget End
1986-03-31
Support Year
4
Fiscal Year
1985
Total Cost
Indirect Cost

  Institution

Name
University of Texas Medical Br Galveston
Department
Type
Schools of Medicine
DUNS #
041367053
City
Galveston
State
TX
Country
United States
Zip Code
77555

  Publications

Jenq, C B; Coggeshall, R E (1987) Single vs multiple somatic nerve crushes in the rat. Brain Res 409:250-8
Hulsebosch, C E; Coggeshall, R E; Perez-Polo, J R (1987) Persistence of anti-NGF induced dorsal root axons: possible penetration into the mammalian spinal cord. Brain Res 411:267-74
Jenq, C B; Jenq, L L; Coggeshall, R E (1987) Numerical patterns of axon regeneration that follow sciatic nerve crush in the neonatal rat. Exp Neurol 95:492-9
Jenq, C B; Coggeshall, R E (1987) Permeable tubes increase the length of the gap that regenerating axons can span. Brain Res 408:239-42
Chung, K; Langford, L A; Coggeshall, R E (1987) Primary afferent and propriospinal fibers in the rat dorsal and dorsolateral funiculi. J Comp Neurol 263:68-75
Jenq, C B; Chung, K; Coggeshall, R E (1986) Postnatal loss of axons in normal rat sciatic nerve. J Comp Neurol 244:445-50
Jenq, C B; Coggeshall, R E (1986) Regeneration of transected rat sciatic nerves after using isolated nerve fragments as distal inserts in silicone tubes. Exp Neurol 91:154-62
Hulsebosch, C E; Coggeshall, R E; Chung, K (1986) Numbers of rat dorsal root axons and ganglion cells during postnatal development. Brain Res 391:105-13
Jenq, C B; Coggeshall, R E (1986) The effects of an autologous transplant on patterns of regeneration in rat sciatic nerve. Brain Res 364:45-56
Jenq, C B; Coggeshall, R E (1985) Numbers of regenerated axons in tributary nerves following neonatal sciatic nerve crush in rat. Neurosci Lett 61:43-8

Showing the most recent 10 out of 13 publications