Almost any peripheral hearing loss results in some atrophic effects of auditory portions of the brainstem. The proposed morphological experiments will use experimental mice and guinea pigs to determine: 1) If the dendrites of ventral cochlear neurons are adversely affected by neonatal auditory deprivation, neonatal conductive losses, and/or neonatal cochlear removal; 2) If there is a direct correlational relationship between cochlear atrophy and ventral cochlear nuclear atrophy in deafness mice (dn/dn); 3) If ganglioside tratment can ameliorate transneuronal atrophy in hearing impaired mice and guinea pigs; 4) If there are quantitative and/or qualitative differences in the cochlear nuclei of mice with long-term cochlear removals starring neonatally as compared to those starting in adult mice; and 5) If there are dramatic short-term effects of cochlear removals in mice as there are in chicks. The results of these experiments will document the age-dependent, transneuronal, atrophic effects of peripheral hearing impairments and explore means of ameliorating them.
| Anniko, M; Sjostrom, B; Webster, D (1989) The effects of auditory deprivation on morphological maturation of the ventral cochlear nucleus. Arch Otorhinolaryngol 246:43-7 |
| Webster, D B (1988) Conductive hearing loss affects the growth of the cochlear nuclei over an extended period of time. Hear Res 32:185-92 |
| Webster, D B (1988) Sound amplification negates central effects of a neonatal conductive hearing loss. Hear Res 32:193-5 |
| Hood, L J; Webster, D B (1988) Reversible conductive hearing loss in mice. Ann Otol Rhinol Laryngol 97:281-5 |
| Webster, D B; Sobin, A; Anniko, M (1986) Incomplete maturation of brainstem auditory nuclei in genetically induced early postnatal cochlear degeneration. Acta Otolaryngol 101:429-38 |
| Webster, D B; Packer, D J; Webster, M (1985) Functional anatomy of the external and middle ear. Ear Nose Throat J 64:275-81 |
| Webster, D B (1985) The spiral ganglion and cochlear nuclei of deafness mice. Hear Res 18:19-27 |
