Almost any peripheral hearing loss results in some atrophic effects of auditory portions of the brainstem. The proposed morphological experiments will use experimental mice and guinea pigs to determine: 1) If the dendrites of ventral cochlear neurons are adversely affected by neonatal auditory deprivation, neonatal conductive losses, and/or neonatal cochlear removal; 2) If there is a direct correlational relationship between cochlear atrophy and ventral cochlear nuclear atrophy in deafness mice (dn/dn); 3) If ganglioside tratment can ameliorate transneuronal atrophy in hearing impaired mice and guinea pigs; 4) If there are quantitative and/or qualitative differences in the cochlear nuclei of mice with long-term cochlear removals starring neonatally as compared to those starting in adult mice; and 5) If there are dramatic short-term effects of cochlear removals in mice as there are in chicks. The results of these experiments will document the age-dependent, transneuronal, atrophic effects of peripheral hearing impairments and explore means of ameliorating them.

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Project (R01)
Project #
5R01NS019238-06
Application #
3399251
Study Section
Hearing Research Study Section (HAR)
Project Start
1983-05-01
Project End
1991-07-31
Budget Start
1988-08-01
Budget End
1989-07-31
Support Year
6
Fiscal Year
1988
Total Cost
Indirect Cost
Name
Louisiana State University Hsc New Orleans
Department
Type
Schools of Medicine
DUNS #
782627814
City
New Orleans
State
LA
Country
United States
Zip Code
70112
Anniko, M; Sjostrom, B; Webster, D (1989) The effects of auditory deprivation on morphological maturation of the ventral cochlear nucleus. Arch Otorhinolaryngol 246:43-7
Hood, L J; Webster, D B (1988) Reversible conductive hearing loss in mice. Ann Otol Rhinol Laryngol 97:281-5
Webster, D B (1988) Conductive hearing loss affects the growth of the cochlear nuclei over an extended period of time. Hear Res 32:185-92
Webster, D B (1988) Sound amplification negates central effects of a neonatal conductive hearing loss. Hear Res 32:193-5
Webster, D B; Sobin, A; Anniko, M (1986) Incomplete maturation of brainstem auditory nuclei in genetically induced early postnatal cochlear degeneration. Acta Otolaryngol 101:429-38
Webster, D B; Packer, D J; Webster, M (1985) Functional anatomy of the external and middle ear. Ear Nose Throat J 64:275-81
Webster, D B (1985) The spiral ganglion and cochlear nuclei of deafness mice. Hear Res 18:19-27