Abstract

Experimental allergic encephalomyelitis (EAE), a laboratory model for Multiple Sclerosis (MS), will be used to develop new strategies of chemotherapy. Drugs known to have therapeutic potential for EAE will be administered in any of the following ways: after prior sensitization to the drug, in combination with other agents, or in such a way as to impact selectively on lymphoid system with or without the added benefit of """"""""rescue"""""""" protocols, antidotes, localized heating, or special methods to reduce toxicity. Attempts will be made to overcome the refractory state that supervenes after administration of certain drugs. All the experiments will be aimed at increased therapeutic efficacy and decreased toxicity. The results may provide novel approaches to treatment of MS that are safer and more effective.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Project (R01)
Project #
5R01NS020696-03
Application #
3401243
Study Section
Neurological Sciences Subcommittee 1 (NLS)
Project Start
1984-12-01
Project End
1988-11-30
Budget Start
1986-12-01
Budget End
1988-11-30
Support Year
3
Fiscal Year
1987
Total Cost
Indirect Cost

  Institution

Name
New York Medical College
Department
Type
Schools of Medicine
DUNS #
City
Valhalla
State
NY
Country
United States
Zip Code
10595

  Publications

Levine, S; Saltzman, A (1988) The topography of mercurial lymphadenopathy in brown Norway rats. Lymphology 21:161-8
Levine, S; Saltzman, A (1988) Postinflammatory increase of lymphatic absorption from the peritoneal cavity: role of diaphragmatic stomata. Microcirc Endothelium Lymphatics 4:399-413
Levine, S; Saltzman, A (1987) A method for evaluating regional effects of cytotoxic drugs on proliferating cells in lymph nodes. J Pharmacol Methods 17:173-8
Levine, S; Saad, A; Rappaport, I (1987) The effects of metallic tin on background plaque-forming cells, immunoglobulins and the immune response. Immunol Invest 16:201-12
Levine, S; Saltzman, A (1987) Increased hemagglutinins after intraperitoneal immunization in postinflammatory state. J Immunol Methods 105:179-82
Levine, S; Saltzman, A (1987) Nonspecific stress prevents relapses of experimental allergic encephalomyelitis in rats. Brain Behav Immun 1:336-41
Levine, S; Saltzman, A (1986) Percutaneous inoculation of lymph nodes. J Immunol Methods 92:227-30
Levine, S; Gherson, J (1986) Morphologic effects of mitoxantrone and a related anthracenedione on lymphoid tissues. Int J Immunopharmacol 8:999-1007
Levine, S (1986) A relapsing form of allergic encephalomyelitis in rats due to enhanced absorption of inoculum. J Neuropathol Exp Neurol 45:247-57
Levine, S; Abreu, S L; Saltzman, A (1986) Adoptive transfer of allergic encephalomyelitis by inoculation of cells into lymph nodes. Immunol Invest 15:439-46

Showing the most recent 10 out of 12 publications