It is proposed to study the role of cyclic AMP, calcium and protein phosphorylation in the peripheral nervous tissue. One approach is to determine the effect of neuronal activity on the state of phosphorylation Protein I in the superior cervical ganglia. A second approach is to determine the site of such phosphorylation in the Protein I molecule. A third approach is to determine the effect of impulse conduction on the state of phosphorylation of Protein I in the vas deferens. A fourth approach is to determine the site of such phosphorylation in the Protein I molecule. A fifth approach is to carry out cytochemical and radioimmunoassay studies, at the light and electromicroscope levels, on the distribution in the peripheral nervous system of Protein X, a protein found in mammalian brain.

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Project (R01)
Project #
5R01NS021550-03
Application #
3402749
Study Section
Neurological Sciences Subcommittee 1 (NLS)
Project Start
1984-05-01
Project End
1992-06-30
Budget Start
1986-07-01
Budget End
1987-06-30
Support Year
3
Fiscal Year
1986
Total Cost
Indirect Cost
Name
Rockefeller University
Department
Type
Graduate Schools
DUNS #
071037113
City
New York
State
NY
Country
United States
Zip Code
10065
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