A better understanding of the developing neonatal respiratory system has resulted in a better management of the premature infant respiratory problems. Unfortunately, a similar statement cannot be made about the management of neonatal intracerebral damage, or of its devastating clinical sequelae. An obvious reason for this discrepancy lies in the fact that our understanding of the neonatal brain structure and vasculature is inadequate, and in some areas (vulnerability of matrix capillaries) lacking. We all are painfully aware that the number of children with """"""""Minimal Brain Damage: is increasing, as more and more premature infants survive because of improvements in the management of their respiratory problems.
The aims of this research are; a. study the structural organization of the developing (normal and abnormal) cerebellar and cerebral cortices and their vasculature, b, acquire a better understanding of the neonatal brain, c. utilize that knowledge to improve the management of neonatal intracerebral damage. The investigative tools are; the Golgi method, computer enhance neuronal morphometry, electron microscopy, and immunohistochemistry. The proposed studies are; A. Neurogenesis of Golgi cells of the developing neonatal cerebellum. B. Structural organization of marginal heterotopias of the cerebral cortex. Cortical heterotopias have been described in epilepsy, dyslexia, cerebral palsy, and mental retardation, however their structure remains poorly understood. C. Study cerebral cortex (frontal, motor, Broca's auditory and visual areas) Down's syndrome. D. Study neonatal development and distribution of short circuit cortical neurons. E. Continuation 'maps' reconstructions neonatal brain at various ages to be used as reference data. F. Continuation of neonatal brains collection for future studies. G. Preliminary light and EM immunohistochemical experimental studies of the embryonic vascularization of the cerebral cortex of 11-12 day old mouse embryos.
|Marin-Padilla, Miguel; Parisi, Joseph E; Armstrong, Dawna L et al. (2002) Shaken infant syndrome: developmental neuropathology, progressive cortical dysplasia, and epilepsy. Acta Neuropathol (Berl) 103:321-32|
|Marin-Padilla, M (2000) Perinatal brain damage, cortical reorganization (acquired cortical dysplasias), and epilepsy. Adv Neurol 84:153-72|
|Marin-Padilla, M (1999) Developmental neuropathology and impact of perinatal brain damage. III: gray matter lesions of the neocortex. J Neuropathol Exp Neurol 58:407-29|
|North, T; Gu, T L; Stacy, T et al. (1999) Cbfa2 is required for the formation of intra-aortic hematopoietic clusters. Development 126:2563-75|
|Marin-Padilla, M (1999) [The development of the human cerebral cortex. A cytoarchitectonic theory] Rev Neurol 29:208-16|
|Marin-Padilla, M (1998) Cajal-Retzius cells and the development of the neocortex. Trends Neurosci 21:64-71|
|Marin-Padilla, M (1997) Developmental neuropathology and impact of perinatal brain damage. II: white matter lesions of the neocortex. J Neuropathol Exp Neurol 56:219-35|
|Marin-Padilla, M (1997) [Pathology and pathogenesis of secondary epilepsy to hypoxic-ischemic encephalopathies] Rev Neurol 25:673-82|
|Yergeau, D A; Hetherington, C J; Wang, Q et al. (1997) Embryonic lethality and impairment of haematopoiesis in mice heterozygous for an AML1-ETO fusion gene. Nat Genet 15:303-6|
|Wang, Q; Stacy, T; Binder, M et al. (1996) Disruption of the Cbfa2 gene causes necrosis and hemorrhaging in the central nervous system and blocks definitive hematopoiesis. Proc Natl Acad Sci U S A 93:3444-9|
Showing the most recent 10 out of 25 publications