Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Project (R01)
Project #
5R01NS029473-07
Application #
2037436
Study Section
Pharmacology A Study Section (PHRA)
Program Officer
Kitt, Cheryl A
Project Start
1991-09-30
Project End
1999-08-31
Budget Start
1996-09-01
Budget End
1997-08-31
Support Year
7
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Case Western Reserve University
Department
Physiology
Type
Schools of Medicine
DUNS #
077758407
City
Cleveland
State
OH
Country
United States
Zip Code
44106
Klemic, K G; Kirsch, G E; Jones, S W (2001) U-type inactivation of Kv3.1 and Shaker potassium channels. Biophys J 81:814-26
Kirsch, G E (1999) Ion channel defects in cardiac arrhythmia. J Membr Biol 170:181-90
Klemic, K G; Shieh, C C; Kirsch, G E et al. (1998) Inactivation of Kv2.1 potassium channels. Biophys J 74:1779-89
Dumaine, R; Kirsch, G E (1998) Mechanism of lidocaine block of late current in long Q-T mutant Na+ channels. Am J Physiol 274:H477-87
Kramer, J W; Post, M A; Brown, A M et al. (1998) Modulation of potassium channel gating by coexpression of Kv2.1 with regulatory Kv5.1 or Kv6.1 alpha-subunits. Am J Physiol 274:C1501-10
Chen, S; Hartmann, H A; Kirsch, G E (1997) Cysteine mapping in the ion selectivity and toxin binding region of the cardiac Na+ channel pore. J Membr Biol 155:11-25
Pascual, J M; Shieh, C C; Kirsch, G E et al. (1997) Contribution of the NH2 terminus of Kv2.1 to channel activation. Am J Physiol 273:C1849-58
Shieh, C C; Klemic, K G; Kirsch, G E (1997) Role of transmembrane segment S5 on gating of voltage-dependent K+ channels. J Gen Physiol 109:767-78
Post, M A; Kirsch, G E; Brown, A M (1996) Kv2.1 and electrically silent Kv6.1 potassium channel subunits combine and express a novel current. FEBS Lett 399:177-82
Dumaine, R; Wang, Q; Keating, M T et al. (1996) Multiple mechanisms of Na+ channel--linked long-QT syndrome. Circ Res 78:916-24

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