Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Project (R01)
Project #
5R01NS032888-02
Application #
2271386
Study Section
Neurological Sciences Subcommittee 1 (NLS)
Project Start
1995-08-01
Project End
1998-07-31
Budget Start
1996-08-01
Budget End
1997-07-31
Support Year
2
Fiscal Year
1996
Total Cost
Indirect Cost

  Institution

Name
University of Florida
Department
Pharmacology
Type
Schools of Medicine
DUNS #
073130411
City
Gainesville
State
FL
Country
United States
Zip Code
32611

  Publications

Damaj, M Imad; Wiley, Jenny L; Martin, Billy R et al. (2005) In vivo characterization of a novel inhibitor of CNS nicotinic receptors. Eur J Pharmacol 521:43-8
Papke, Roger L; Buhr, Joshua D; Francis, Michael M et al. (2005) The effects of subunit composition on the inhibition of nicotinic receptors by the amphipathic blocker 2,2,6,6-tetramethylpiperidin-4-yl heptanoate. Mol Pharmacol 67:1977-90
Kem, William R; Mahnir, Vladimir M; Prokai, Laszlo et al. (2004) Hydroxy metabolites of the Alzheimer's drug candidate 3-[(2,4-dimethoxy)benzylidene]-anabaseine dihydrochloride (GTS-21): their molecular properties, interactions with brain nicotinic receptors, and brain penetration. Mol Pharmacol 65:56-67
Uteshev, Vladimir V; Meyer, Edwin M; Papke, Roger L (2003) Regulation of neuronal function by choline and 4OH-GTS-21 through alpha 7 nicotinic receptors. J Neurophysiol 89:1797-806
Frazier, Charles J; Strowbridge, Ben W; Papke, Roger L (2003) Nicotinic receptors on local circuit neurons in dentate gyrus: a potential role in regulation of granule cell excitability. J Neurophysiol 89:3018-28
Uteshev, Vladimir V; Meyer, Edwin M; Papke, Roger L (2002) Activation and inhibition of native neuronal alpha-bungarotoxin-sensitive nicotinic ACh receptors. Brain Res 948:33-46
Papke, Roger L; Porter Papke, Julia K (2002) Comparative pharmacology of rat and human alpha7 nAChR conducted with net charge analysis. Br J Pharmacol 137:49-61
Papke, Roger L (2002) Enhanced inhibition of a mutant neuronal nicotinic acetylcholine receptor by agonists: protection of function by (E)-N-methyl-4-(3-pyridinyl)-3-butene-1-amine (TC-2403). J Pharmacol Exp Ther 301:765-73
Papke, R L; Meyer, E; Nutter, T et al. (2000) alpha7 receptor-selective agonists and modes of alpha7 receptor activation. Eur J Pharmacol 393:179-95
Webster, J C; Francis, M M; Porter, J K et al. (1999) Antagonist activities of mecamylamine and nicotine show reciprocal dependence on beta subunit sequence in the second transmembrane domain. Br J Pharmacol 127:1337-48

Showing the most recent 10 out of 16 publications