Abstract

Neuroblastoma (NB) is the most common solid tumor in children and accounts for 15% of all childhood cancer deaths. Inheritance has been implicated in NB although the location of predisposing gene(s) has not been identified. Constitutional translocations have been valuable tools for gene discovery in a large number of human diseases, where it has been shown repeatedly that the interrupted gene is responsible for the disease. The PI has identified 2 NB subjects with constitutional translocations. The goal of the proposed work is to characterize the breakpoints and identify the genes disrupted by the translocations.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Project (R01)
Project #
5R01NS035791-02
Application #
2635789
Study Section
Neurology C Study Section (NEUC)
Program Officer
Jacobs, Tom P
Project Start
1997-01-01
Project End
1999-12-31
Budget Start
1998-01-01
Budget End
1998-12-31
Support Year
2
Fiscal Year
1998
Total Cost
Indirect Cost

  Institution

Name
Cleveland Clinic Lerner
Department
Type
DUNS #
017730458
City
Cleveland
State
OH
Country
United States
Zip Code
44195

  Publications

Sossey-Alaoui, Khalid; Li, Xiurong; Cowell, John K (2007) c-Abl-mediated phosphorylation of WAVE3 is required for lamellipodia formation and cell migration. J Biol Chem 282:26257-65
Sossey-Alaoui, Khalid; Safina, Alfiya; Li, Xiurong et al. (2007) Down-regulation of WAVE3, a metastasis promoter gene, inhibits invasion and metastasis of breast cancer cells. Am J Pathol 170:2112-21
Faitar, Silviu L; Sossey-Alaoui, Khalid; Ranalli, Tamara A et al. (2006) EVI5 protein associates with the INCENP-aurora B kinase-survivin chromosomal passenger complex and is involved in the completion of cytokinesis. Exp Cell Res 312:2325-35
Faitar, Silviu L; Dabbeekeh, Jeremy T S; Ranalli, Tamara A et al. (2005) EVI5 is a novel centrosomal protein that binds to alpha- and gamma-tubulin. Genomics 86:594-605
Sossey-Alaoui, Khalid; Ranalli, Tamara A; Li, Xiurong et al. (2005) WAVE3 promotes cell motility and invasion through the regulation of MMP-1, MMP-3, and MMP-9 expression. Exp Cell Res 308:135-45
Sossey-Alaoui, Khalid; Li, Xiurong; Ranalli, Tamara A et al. (2005) WAVE3-mediated cell migration and lamellipodia formation are regulated downstream of phosphatidylinositol 3-kinase. J Biol Chem 280:21748-55
Sossey-Alaoui, Khalid; Su, Guanfang; Malaj, Eda et al. (2002) WAVE3, an actin-polymerization gene, is truncated and inactivated as a result of a constitutional t(1;13)(q21;q12) chromosome translocation in a patient with ganglioneuroblastoma. Oncogene 21:5967-74
Somerville, R P; Chernova, O; Liu, S et al. (2000) Identification of the promoter, genomic structure, and mouse ortholog of LGI1. Mamm Genome 11:622-7
Liu, S; Cowell, J K (2000) Cloning and characterization of the TATA-less promoter from the human GFI1 proto-oncogene. Ann Hum Genet 64:83-6
Chelsea, D M; Roberts, T; Cowell, J K (2000) A new region of synteny between human chromosome 1p22 and mouse chromosome 5. Int J Mol Med 5:553-6

Showing the most recent 10 out of 12 publications