Abstract

This is an application with three specific aims. In the first specific aim the Principal Investigator will assess quantitative viral load in plasma and CSF over time, and derive estimates of cumulative viral load. These will be correlated with measures of CNS dysfunction. In the second specific aim, the Investigator will use an assay of neurotoxicity based on cultured cells and relate the cytotoxicity of CSF from HIV seropositive individuals to viral load. In the third specific aim, the relationship between cytotoxicity and neurological disease will be measured.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Project (R01)
Project #
5R01NS036518-02
Application #
2892261
Study Section
AIDS and Related Research Study Section 7 (ARRG)
Program Officer
Nunn, Michael
Project Start
1998-04-01
Project End
2002-03-31
Budget Start
1999-04-01
Budget End
2002-03-31
Support Year
2
Fiscal Year
1999
Total Cost
Indirect Cost

  Institution

Name
University of North Carolina Chapel Hill
Department
Neurology
Type
Schools of Medicine
DUNS #
078861598
City
Chapel Hill
State
NC
Country
United States
Zip Code
27599

  Publications

Parsons, Thomas D; Tucker, Karen A; Hall, Colin D et al. (2006) Neurocognitive functioning and HAART in HIV and hepatitis C virus co-infection. AIDS 20:1591-5
Inman, Tina Hanlon; Esther, Julie K; Robertson, Wendy T et al. (2002) The Minnesota Multiphasic Personality Inventory-2 across the human immunodeficiency virus spectrum. Assessment 9:24-30
Corder, E H; Robertson, K; Lannfelt, L et al. (1998) HIV-infected subjects with the E4 allele for APOE have excess dementia and peripheral neuropathy. Nat Med 4:1182-4