Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Project (R01)
Project #
5R01NS038008-05
Application #
6540024
Study Section
AIDS and Related Research Study Section 7 (ARRG)
Program Officer
Nunn, Michael
Project Start
1998-07-15
Project End
2003-06-30
Budget Start
2002-07-01
Budget End
2003-06-30
Support Year
5
Fiscal Year
2002
Total Cost
$344,031
Indirect Cost

  Institution

Name
Johns Hopkins University
Department
Veterinary Sciences
Type
Schools of Medicine
DUNS #
045911138
City
Baltimore
State
MD
Country
United States
Zip Code
21218

  Publications

Bonavia, A; Bullock, B T; Gisselman, K M et al. (2005) A single amino acid change and truncated TM are sufficient for simian immunodeficiency virus to enter cells using CCR5 in a CD4-independent pathway. Virology 341:12-23
Carruth, Lucy M; Zink, M Christine; Tarwater, Patrick M et al. (2005) SIV-specific T lymphocyte responses in PBMC and lymphoid tissues of SIV-infected pigtailed macaques during suppressive combination antiretroviral therapy. J Med Primatol 34:109-21
Rue, Sarah M; Roos, Jason W; Tarwater, Patrick M et al. (2005) Phosphorylation and proteolytic cleavage of gag proteins in budded simian immunodeficiency virus. J Virol 79:2484-92
Overholser, Emily D; Babas, Tahar; Zink, M Christine et al. (2005) CD4-independent entry and replication of simian immunodeficiency virus in primary rhesus macaque astrocytes are regulated by the transmembrane protein. J Virol 79:4944-51
Overholser, Emily D; Coleman, Gary D; Bennett, Jennifer L et al. (2003) Expression of simian immunodeficiency virus (SIV) nef in astrocytes during acute and terminal infection and requirement of nef for optimal replication of neurovirulent SIV in vitro. J Virol 77:6855-66
Shen, Anding; Zink, M Christine; Mankowski, Joseph L et al. (2003) Resting CD4+ T lymphocytes but not thymocytes provide a latent viral reservoir in a simian immunodeficiency virus-Macaca nemestrina model of human immunodeficiency virus type 1-infected patients on highly active antiretroviral therapy. J Virol 77:4938-49
Babas, Tahar; Munoz, Daniel; Mankowski, Joseph L et al. (2003) Role of microglial cells in selective replication of simian immunodeficiency virus genotypes in the brain. J Virol 77:208-16
Clements, Janice E; Babas, Tahar; Mankowski, Joseph L et al. (2002) The central nervous system as a reservoir for simian immunodeficiency virus (SIV): steady-state levels of SIV DNA in brain from acute through asymptomatic infection. J Infect Dis 186:905-13
Mankowski, Joseph L; Clements, Janice E; Zink, M Christine (2002) Searching for clues: tracking the pathogenesis of human immunodeficiency virus central nervous system disease by use of an accelerated, consistent simian immunodeficiency virus macaque model. J Infect Dis 186 Suppl 2:S199-208
Zink, M Christine; Clements, Janice E (2002) A novel simian immunodeficiency virus model that provides insight into mechanisms of human immunodeficiency virus central nervous system disease. J Neurovirol 8 Suppl 2:42-8

Showing the most recent 10 out of 14 publications