Post-stroke depression (PSD) is a prevalent condition that has pervasive effects on patients' functional recovery and health-related quality of life (HRQOL), as well as outcomes of caregivers. The long-term objective of this proposal is to evaluation the effectiveness of a multi-faceted, 12 week intervention (AIM) that seeks to activate patients to be aware of PSD, initiate antidepressant treatment, and monitor treatment side effects and compliance.
The specific aims are to improve: 1) depression symptoms, and 2) stroke-specific quality of life outcomes in patients with PSD. We will enroll 244 ischemic stroke patients who exhibit PSD 1 month post-stroke and randomize them to the AIM intervention vs. usual care. Patients received standardized assessments based on a conceptual framework of stress and coping. Variables include social support, stroke severity, depression, HRQOL, life satisfaction and functional outcomes. Primary depression outcomes are determined 3 months following randomization. We will also examine the durability of the intervention by comparing outcomes at 9 months following randomization. The study protocol requires assembly of a prospective cohort of ischemic stroke patients with and without PSD. Thus, a secondary objective of this study is to capitalize on this opportunity by assessing outcomes in non-depressed stroke survivors (n=244) and stroke caregivers (n=340). These secondary aims are to evaluate the effects of PSD by comparing: 1) outcomes in depressed and non-depressed patients, and 2) in caregivers of depressed and non-depressed patients. Secondary analyses will use the rich post-stroke database to evaluate longitudinal depression and HRQOL outcomes in patients and caregivers, examine the relationship of patient and caregiver outcomes post-stroke, and compare the health care utilization of patients with and without PSD.
| Chung, Misook L; Bakas, Tamilyn; Plue, Laura D et al. (2016) Effects of Self-esteem, Optimism, and Perceived Control on Depressive Symptoms in Stroke Survivor-Spouse Dyads. J Cardiovasc Nurs 31:E8-E16 |
| Johnson, Elizabeth A; Bakas, Tamilyn; Williams, Linda S (2011) Psychometric evaluation of the appraisal of health scale in stroke survivors. J Nurs Meas 19:146-59 |
| Schmid, A A; Kroenke, K; Hendrie, H C et al. (2011) Poststroke depression and treatment effects on functional outcomes. Neurology 76:1000-5 |
| Golomb, Meredith R; Garg, Bhuwan P; Saha, Chandan et al. (2008) Cerebral palsy after perinatal arterial ischemic stroke. J Child Neurol 23:279-86 |
| Golomb, Meredith R; Garg, Bhuwan P; Edwards-Brown, Mary et al. (2008) Very early arterial ischemic stroke in premature infants. Pediatr Neurol 38:329-34 |
| Nwosu, Michelle E; Williams, Linda S; Edwards-Brown, Mary et al. (2008) Neonatal sinovenous thrombosis: presentation and association with imaging. Pediatr Neurol 39:155-61 |
| Golomb, Meredith R; Garg, Bhuwan P; Carvalho, Karen S et al. (2007) Perinatal stroke and the risk of developing childhood epilepsy. J Pediatr 151:409-13, 413.e1-2 |
| Golomb, Meredith R; Saha, Chandan; Garg, Bhuwan P et al. (2007) Association of cerebral palsy with other disabilities in children with perinatal arterial ischemic stroke. Pediatr Neurol 37:245-9 |
| McGuire, Lisa M; Williams, Linda S; Walsh, Laurence E et al. (2007) The impact of Pelizaeus-Merzbacher disease on the family. Pediatr Neurol 36:101-5 |
| Fitzgerald, Karima C; Williams, Linda S; Garg, Bhuwan P et al. (2007) Epilepsy in children with delayed presentation of perinatal stroke. J Child Neurol 22:1274-80 |
Showing the most recent 10 out of 19 publications
