Dementia with Lewy Bodies (DLB) represents the second most common cause of dementia. The sleep/wake continuum plays an integral, though seldom explicitly recognized role in characterizing DLB, with both fluctuations in alertness and hallucinatory experiences (often accompanied by dream-enactment behaviors) considered core features of the condition. In this study, we will compare patients meeting clinical criteria for DLB (n=50), idiopathic Parkinson's Disease (IPD) (n=50) and elderly controls (n=20) to examine potential pathophysiologic mechanisms underlying these observations. Patients and controls will be studied at entry in an intensive, 72-hour laboratory protocol with polysomnographic and neurobehavioral measurements and followed-up 3 years later neurobehaviorally.
Our Specific Aims are: 1) to compare polysomnographically excessive daytime sleepiness (EDS) and nocturnal sleep in DLB, IPD and controls;2) to test whether fluctuation in mental status in DLB is related to EDS;3) to predict whether declining cognition over 3 years is predicted by polysomnographic and neurobehavioral markers at entry. The results of this study will inform basic sleep/wake science by investigating potential substrates underlying the observed pathophysiology seen in DLB and IPD. The proposed work will also provide important clinical insights into disease correlates and disease course across the broad spectrum of Parkinsonism.

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Project (R01)
Project #
5R01NS050595-05
Application #
7877786
Study Section
Neural Basis of Psychopathology, Addictions and Sleep Disorders Study Section (NPAS)
Program Officer
Gnadt, James W
Project Start
2006-07-15
Project End
2013-06-30
Budget Start
2010-07-01
Budget End
2013-06-30
Support Year
5
Fiscal Year
2010
Total Cost
$330,924
Indirect Cost
Name
Emory University
Department
Neurology
Type
Schools of Medicine
DUNS #
066469933
City
Atlanta
State
GA
Country
United States
Zip Code
30322
Bliwise, Donald L; Greer, Sophia A; Scullin, Michael K et al. (2017) Habitual and Recent Sleep Durations: Graded and Interactive Risk for Impaired Glycemic Control in a Biracial Population. Am J Med 130:564-571
Scullin, Michael K; Bliwise, Donald L (2015) Sleep, cognition, and normal aging: integrating a half century of multidisciplinary research. Perspect Psychol Sci 10:97-137
Scullin, Michael K; Fairley, Jacqueline A; Trotti, Lynn Marie et al. (2015) Sleep correlates of trait executive function and memory in Parkinson's disease. J Parkinsons Dis 5:49-54
Bliwise, Donald L; Holm-Larsen, Tove; Goble, Sandra et al. (2015) Short time to first void is associated with lower whole-night sleep quality in nocturia patients. J Clin Sleep Med 11:53-5
Bliwise, Donald L; Friedman, Leah; Hernandez, Beatriz et al. (2014) Nocturia reported in nightly sleep diaries: common occurrence with significant implications? Health Psychol 33:1362-5
Bliwise, Donald L; Holm-Larsen, Tove; Goble, Sandra (2014) Increases in duration of first uninterrupted sleep period are associated with improvements in PSQI-measured sleep quality. Sleep Med 15:1276-8
Fairley, Jacqueline A; Georgoulas, George; Smart, Otis L et al. (2014) Wavelet analysis for detection of phasic electromyographic activity in sleep: influence of mother wavelet and dimensionality reduction. Comput Biol Med 48:77-84
Bliwise, Donald L; Zhang, Rebecca H; Kutner, Nancy G (2014) Medications associated with restless legs syndrome: a case-control study in the US Renal Data System (USRDS). Sleep Med 15:1241-5
Bliwise, Donald L; Scullin, Michael K; Factor, Stewart A (2014) Internal consistency of the University of Michigan RBD Questionnaire. J Neurol 261:1439-41
Bliwise, Donald L; Scullin, Michael K; Trotti, Lynn Marie (2014) Fluctuations in cognition and alertness vary independently in dementia with Lewy bodies. Mov Disord 29:83-9

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