Despite significant progress in stroke prevention and its acute treatment, stroke remains the third leading cause of death and the leading cause of adult morbidity worldwide. Fundamental advances in stroke will require collecting and pooling advanced phenotype (e.g., neuroimaging) and genetic data from multiple centers. Description of and access to the data will also require a common stroke-specific lexicon. We have therefore initiated efforts to promote sharing and distribution of imaging and genetic data, www.strokedatabase.org and www.strokegenetics.org, and a lexicographic categorization tool, ccs.martinos.org. Using these portals, data and tools are available to individual research groups. We seek to expand our ability to distribute data and tools by linking our efforts to the infrastructure provided by the Biomedical Informatics Research Network (BIRN). We will initially distribute data using the BIRN service, Extensible Neuroimaging Archive Toolkit (XNAT) Central, to insure our data compatibility with the BIRN Data Repository (BDR). We will then work with BIRN domain experts to begin to incorporate stroke data specific terms into the BIRN ontology to ensure successful port and distribution of our data using the BDR. Linking our existing portals with BIRN resources has the potential to greatly facilitate data sharing which will benefit the understanding of stroke and speed discovery of new therapeutic interventions.

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Project (R01)
Project #
5R01NS063925-02
Application #
7942865
Study Section
Special Emphasis Panel (ZRG1-BST-G (50))
Program Officer
Liu, Yuan
Project Start
2009-09-30
Project End
2012-08-31
Budget Start
2010-09-01
Budget End
2012-08-31
Support Year
2
Fiscal Year
2010
Total Cost
$761,010
Indirect Cost
Name
Massachusetts General Hospital
Department
Type
DUNS #
073130411
City
Boston
State
MA
Country
United States
Zip Code
02199
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