Abstract

Public Health Relevance

This study is relevant to public health. It addresses the mechanisms of regulation of neuronal gap junctions (electrical synapses) during development and traumatic brain injury and the role of gap junctions in traumatic brain injury. This research may have clinical importance given that gap junction coupling increases during brain injury, but the mechanisms of increase and the role of neuronal gap junctions in traumatic brain injury are not yet understood.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Project (R01)
Project #
5R01NS064256-02
Application #
7895093
Study Section
Neurotransporters, Receptors, and Calcium Signaling Study Section (NTRC)
Program Officer
Hicks, Ramona R
Project Start
2009-07-16
Project End
2012-06-30
Budget Start
2010-07-01
Budget End
2012-06-30
Support Year
2
Fiscal Year
2010
Total Cost
$375,000
Indirect Cost

  Institution

Name
University of Kansas
Department
Physiology
Type
Schools of Medicine
DUNS #
016060860
City
Kansas City
State
KS
Country
United States
Zip Code
66160

  Publications

Belousov, Andrei B; Fontes, Joseph D (2014) Neuronal gap junction coupling as the primary determinant of the extent of glutamate-mediated excitotoxicity. J Neural Transm (Vienna) 121:837-46
Belousov, Andrei B; Fontes, Joseph D (2013) Neuronal gap junctions: making and breaking connections during development and injury. Trends Neurosci 36:227-36
Belousov, Andrei B (2012) The regulation and role of neuronal gap junctions during neuronal injury. Channels (Austin) 6:390-2
Belousov, Andrei B; Wang, Yongfu; Song, Ji-Hoon et al. (2012) Neuronal gap junctions play a role in the secondary neuronal death following controlled cortical impact. Neurosci Lett 524:16-9
Song, Ji-Hoon; Wang, Yongfu; Fontes, Joseph D et al. (2012) Regulation of connexin 36 expression during development. Neurosci Lett 513:17-9
Belousov, Andrei B (2012) Novel model for the mechanisms of glutamate-dependent excitotoxicity: role of neuronal gap junctions. Brain Res 1487:123-30
Wang, Yongfu; Song, Ji-Hoon; Denisova, Janna V et al. (2012) Neuronal gap junction coupling is regulated by glutamate and plays critical role in cell death during neuronal injury. J Neurosci 32:713-25
Park, Won-Mee; Wang, Yongfu; Park, Soodong et al. (2011) Interplay of chemical neurotransmitters regulates developmental increase in electrical synapses. J Neurosci 31:5909-20
Wang, Yongfu; Belousov, Andrei B (2011) Deletion of neuronal gap junction protein connexin 36 impairs hippocampal LTP. Neurosci Lett 502:30-2
Michaelis, E K; Wang, X; Pal, R et al. (2011) Neuronal Glud1 (glutamate dehydrogenase 1) over-expressing mice: increased glutamate formation and synaptic release, loss of synaptic activity, and adaptive changes in genomic expression. Neurochem Int 59:473-81

Showing the most recent 10 out of 11 publications