Abstract

We propose to develop a novel MRI reporter gene system that uses MRI to monitor gene expression and the status of cell grafts in vivo. Current MRI technology is capable of high spatial resolution at 10-

Public Health Relevance

The proposed project seeks to evaluate the novel transgenic MRI reporter and its application as a marker for noninvasive monitoring of embryonic stem (ES) cell grafts. Thus, the development of ES cells can be monitored and traced.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Project (R01)
Project #
5R01NS064991-03
Application #
8063171
Study Section
Nanotechnology Study Section (NANO)
Program Officer
Owens, David F
Project Start
2009-05-16
Project End
2013-04-30
Budget Start
2011-05-01
Budget End
2012-04-30
Support Year
3
Fiscal Year
2011
Total Cost
$377,300
Indirect Cost

  Institution

Name
Emory University
Department
Genetics
Type
Schools of Medicine
DUNS #
066469933
City
Atlanta
State
GA
Country
United States
Zip Code
30322

  Publications

Cho, In K; Wang, Silun; Mao, Hui et al. (2016) Genetic engineered molecular imaging probes for applications in cell therapy: emphasis on MRI approach. Am J Nucl Med Mol Imaging 6:234-261
Chen, Yiju; Carter, Richard L; Cho, In K et al. (2014) Cell-based therapies for Huntington's disease. Drug Discov Today 19:980-4
Cho, In K; Moran, Sean P; Paudyal, Ramesh et al. (2014) Longitudinal monitoring of stem cell grafts in vivo using magnetic resonance imaging with inducible maga as a genetic reporter. Theranostics 4:972-89
Chan, Anthony W S (2013) Progress and prospects for genetic modification of nonhuman primate models in biomedical research. ILAR J 54:211-23
Putkhao, Kittiphong; Chan, Anthony W S; Agca, Yuksel et al. (2013) Cryopreservation of transgenic Huntington's disease rhesus macaque sperm-A Case Report. Cloning Transgenes 2:
Chan, Anthony W S; Cheng, Pei-Hsun; Neumann, Adam et al. (2010) Reprogramming Huntington monkey skin cells into pluripotent stem cells. Cell Reprogram 12:509-17