Obesity, male gender, and middle age, the typical demographic features of the commercial driver, are also the three strongest risk factors for obstructive sleep apnea. While sleep apnea afflicts 2-4% of all middle aged employed adults, as many as 60-80% of commercial drivers may have the condition, and most of them are unaware that they have it. The driver with sleep apnea experiences repetitive airway closure during sleep, subsequent fall in oxygen saturation and arousal from sleep. Morbidity from this condition is substantial, and includes hypertension, myocardial infarction, stroke, insulin resistance, and fall-asleep crashes. A safe and effective therapy for sleep apnea is available in the form of continuous positive airway pressure, a pneumatic splint that prevents airway collapse during sleep. This therapy confers benefits such as reduction in blood pressure, insulin resistance and sleepiness and may attenuate the risk of cardiovascular disease and crashes. The morbidity of sleep apnea and the availability of effective therapy argue strongly for the development of effective screening strategies for sleep apnea in commercial drivers. An in-laboratory, full overnight sleep study is the current diagnostic gold standard, but is expensive, inconvenient and inaccessible. Simpler techniques may be applied within minutes during occupational health screening, and may be combined with technologies self-assembled in the home by the driver. However, the usefulness or cost of these strategies has not been evaluated in occupational screening. Therefore, our specific aims are to: 1) Evaluate how well self-assembled technologies used in the home setting identify sleep apnea in commercial drivers, 2) Determine whether an occupational screening evaluation can be combined with home diagnostic technologies to reduce the number of patients that need testing 3) Determine the relative economic costs of these screening strategies ? ? ?

Agency
National Institute of Health (NIH)
Institute
National Institute for Occupational Safety and Health (NIOSH)
Type
Research Project (R01)
Project #
1R01OH009149-01
Application #
7269108
Study Section
Special Emphasis Panel (ZOH1-GGB (50))
Program Officer
Robison, William
Project Start
2007-08-01
Project End
2010-07-31
Budget Start
2007-08-01
Budget End
2008-07-31
Support Year
1
Fiscal Year
2007
Total Cost
$315,000
Indirect Cost
Name
University of Pennsylvania
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
042250712
City
Philadelphia
State
PA
Country
United States
Zip Code
19104
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