The overall goal is to synthesize experimental data at the membrane and molecular level into predictive mathematical models of the kidney that are useful in understanding both its normal and diseased function. The general purpose of the proposed research is to develop for the first time a mathematical and computer model that includes a realistic architecture, cellular and paracellular transport of water and solutes, and exchange of solutes and water between plasma and red blood cells. The development builds on simpler models, but requires the parallel processing capabilities of supercomputers.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Research Project (R01)
Project #
2R01RR006589-05A1
Application #
2283246
Study Section
Special Emphasis Panel (ZRG7-SSS-9 (04))
Project Start
1991-04-01
Project End
1998-08-31
Budget Start
1995-09-30
Budget End
1996-08-31
Support Year
5
Fiscal Year
1995
Total Cost
Indirect Cost
Name
Weill Medical College of Cornell University
Department
Physiology
Type
Schools of Medicine
DUNS #
201373169
City
New York
State
NY
Country
United States
Zip Code
10065
Stephenson, J L; Wang, H; Tewarson, R P (1995) Effect of vasa recta flow on concentrating ability of models of renal inner medulla. Am J Physiol 268:F698-709
Jen, J F; Wang, H; Tewarson, R P et al. (1995) Comparison of central core and radially separated models of renal inner medulla. Am J Physiol 268:F693-7
Stephenson, J L; Jen, J F; Wang, H et al. (1995) Convective uphill transport of NaCl from ascending thin limb of loop of Henle. Am J Physiol 268:F680-92
Jen, J F; Stephenson, J L (1994) Externally driven countercurrent multiplication in a mathematical model of the urinary concentrating mechanism of the renal inner medulla. Bull Math Biol 56:491-514