The overall goal is to synthesize experimental data at the membrane and molecular level into predictive mathematical models of the kidney that are useful in understanding both its normal and diseased function. The general purpose of the proposed research is to develop for the first time a mathematical and computer model that includes a realistic architecture, cellular and paracellular transport of water and solutes, and exchange of solutes and water between plasma and red blood cells. The development builds on simpler models, but requires the parallel processing capabilities of supercomputers.
| Jen, J F; Wang, H; Tewarson, R P et al. (1995) Comparison of central core and radially separated models of renal inner medulla. Am J Physiol 268:F693-7 |
| Stephenson, J L; Jen, J F; Wang, H et al. (1995) Convective uphill transport of NaCl from ascending thin limb of loop of Henle. Am J Physiol 268:F680-92 |
| Stephenson, J L; Wang, H; Tewarson, R P (1995) Effect of vasa recta flow on concentrating ability of models of renal inner medulla. Am J Physiol 268:F698-709 |
| Jen, J F; Stephenson, J L (1994) Externally driven countercurrent multiplication in a mathematical model of the urinary concentrating mechanism of the renal inner medulla. Bull Math Biol 56:491-514 |
