The proposal is to use silicon machining to make low capacitance electrodes for patch clamp recording from Xenopus oocyte membranes with the possible inclusion of on-chip amplifiers. The lower capacitance is expected to increase the signal to noise ratio by a factor of 10 at higher frequencies.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Research Project (R01)
Project #
5R01RR012246-02
Application #
2703190
Study Section
Physiology Study Section (PHY)
Project Start
1997-05-15
Project End
2000-04-14
Budget Start
1998-04-15
Budget End
1999-04-14
Support Year
2
Fiscal Year
1998
Total Cost
Indirect Cost
Name
Yale University
Department
Physiology
Type
Schools of Medicine
DUNS #
082359691
City
New Haven
State
CT
Country
United States
Zip Code
06520
Klemic, Kathryn G; Klemic, James F; Reed, Mark A et al. (2002) Micromolded PDMS planar electrode allows patch clamp electrical recordings from cells. Biosens Bioelectron 17:597-604