Abstract

The proposal is to use silicon machining to make low capacitance electrodes for patch clamp recording from Xenopus oocyte membranes with the possible inclusion of on-chip amplifiers. The lower capacitance is expected to increase the signal to noise ratio by a factor of 10 at higher frequencies.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Research Project (R01)
Project #
3R01RR012246-03S1
Application #
6298800
Study Section
Physiology Study Section (PHY)
Program Officer
Marron, Michael T
Project Start
1997-05-15
Project End
2001-04-14
Budget Start
1999-04-15
Budget End
2001-04-14
Support Year
3
Fiscal Year
2000
Total Cost
$95,729
Indirect Cost

  Institution

Name
Yale University
Department
Physiology
Type
Schools of Medicine
DUNS #
082359691
City
New Haven
State
CT
Country
United States
Zip Code
06520

  Publications

Klemic, Kathryn G; Klemic, James F; Reed, Mark A et al. (2002) Micromolded PDMS planar electrode allows patch clamp electrical recordings from cells. Biosens Bioelectron 17:597-604