The goal of this collaborative project is to develop an automated hand-held micromachined electrochemical flow analyzer for high-speed single-cell genomics analysis. Innovative biosensor technology, based on new highly selective and sensitive PNA-dendrimer recognition chemistry, high-density parallel-channel hybridization microreactors, a label-free electrochemical detection of the released targets at downstream microelectrodes, and state-of-the-art microfabrication/micromachining technology will be used for meeting the challenges of rapid and sensitive single-cell nucleic-acid sequencing.
| Poorahong, Sujittra; Santhosh, Padmanabhan; Ramírez, Gabriela Valdés et al. (2011) Development of amperometric ?-ketoglutarate biosensor based on ruthenium-rhodium modified carbon fiber enzyme microelectrode. Biosens Bioelectron 26:3670-3 |
| McWhorter, Todd J; Karasov, William H (2007) Paracellular nutrient absorption in a gum-feeding new world primate, the common marmoset Callithrix jacchus. Am J Primatol 69:1399-411 |
| Wang, J (2000) From DNA biosensors to gene chips. Nucleic Acids Res 28:3011-6 |
| Wang, J; Kawde, A N; Sahlin, E (2000) Renewable pencil electrodes for highly sensitive stripping potentiometric measurements of DNA and RNA. Analyst 125:7-May |
| Wang, J; Grundler, P; Flechsig, G U et al. (2000) Stripping analysis of nucleic acids at a heated carbon paste electrode. Anal Chem 72:3752-6 |
| Wang, J; Jiang, M; Mukherjee, B (2000) On-demand electrochemical release of DNA from gold surfaces. Bioelectrochemistry 52:111-4 |
