This is a proposal for a new investigator R03 to lay the groundwork for a randomized controlled trial of a behavioral treatment to reduce sexual risk taking in men who have sex with men (MSM) who abuse crystal methamphetamine (crystal meth), and are at risk for HIV acquisition. The treatment will incorporate state of the art behavioral risk reduction counseling approaches (e.g. information-motivation-behavioral skills building, IMB;Fisher &Fisher, 1992;Fisher &Fisher, 1993) with behavioral activation therapy to treat depression (a moderator in the IMB model). Behavioral activation is a treatment of depression that focuses on helping individuals reengage in their life (Martell, 2001, 2002). We chose this strategy for MSM who abuse crystal meth because our formative qualitative work revealed that many MSM who abuse crystal meth become unable to enjoy activities that they had previously enjoyed. This lack of enjoyment in activities that do not involve crystal meth use and / or sex contributes to the motivation for continued crystal use and potentially unsafe sex. While the main outcome of the intervention will be to reduce sexual risk taking, additional outcomes will be reduced crystal meth use and reduced depression. The first 6-months will be an intervention development phase, and the next year and a half will be a pilot of the intervention among 20 HIV-uninfected MSM. The study will allow us to demonstrate participant acceptance, ability to recruit, feasibility of treatment delivery with therapists, and clinically significant participant improvement. It will allow for further evaluation of the feasibility of all study procedures, adaptation of the treatment manual, and will provide pilot data for a power analysis for an initial randomized controlled trial. These goals are consistent with NIH guidelines for a stage model of psychosocial treatment development (Rounsaville et al., 2001). PHS 398/2590 (Rev. 09/04) Page Continuation Format Page Principal Investigator/Program Director (Last, First, Middle): Mimiaga, Matthew Project Narrative Crystal meth abuse and dependence is a complex and treatment resistant-problem. One potential cause of its intractability may be that treatments focus on reducing crystal use without emphasizing replacement activities. Based on our formative work, MSM who abuse crystal may have stopped getting pleasure from previously enjoyed activities that do not involve crystal use. Behavioral activation therapy (Martell, Addis, &Jacobson, 2001) is a valid treatment of depression that involves identifying and actively engaging pleasurable events. To our knowledge, an approach that integrates behavioral activation with HIV risk reduction counseling has not yet been studied among men who have sex with men (MSM) who abuse crystal meth.

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Small Research Grants (R03)
Project #
5R03DA023393-02
Application #
7558484
Study Section
Behavioral and Social Science Approaches to Preventing HIV/AIDS Study Section (BSPH)
Program Officer
Jenkins, Richard A
Project Start
2008-02-01
Project End
2011-01-31
Budget Start
2009-02-01
Budget End
2011-01-31
Support Year
2
Fiscal Year
2009
Total Cost
$75,350
Indirect Cost
Name
Fenway Community Health Center
Department
Type
DUNS #
072366156
City
Boston
State
MA
Country
United States
Zip Code
02215
Mimiaga, Matthew J; Reisner, Sari L; Pantalone, David W et al. (2012) A pilot trial of integrated behavioral activation and sexual risk reduction counseling for HIV-uninfected men who have sex with men abusing crystal methamphetamine. AIDS Patient Care STDS 26:681-93
Mimiaga, Matthew J; Reisner, Sari L; Fontaine, Yves-Michel et al. (2010) Walking the line: stimulant use during sex and HIV risk behavior among Black urban MSM. Drug Alcohol Depend 110:30-7
Reisner, Sari L; Mimiaga, Matthew J; Case, Patricia et al. (2010) Sexually transmitted disease (STD) diagnoses and mental health disparities among women who have sex with women screened at an urban community health center, Boston, MA, 2007. Sex Transm Dis 37:5-12
Reisner, Sari L; Mimiaga, Matthew J; Johnson, Carey V et al. (2010) What makes a respondent-driven sampling ""seed"" productive? Example of finding at-risk Massachusetts men who have sex with men. J Urban Health 87:467-79
Reisner, Sari L; Perkovich, Brandon; Mimiaga, Matthew J (2010) A mixed methods study of the sexual health needs of New England transmen who have sex with nontransgender men. AIDS Patient Care STDS 24:501-13
Mimiaga, Matthew J; Reisner, Sari L; Bland, Sean et al. (2009) Health system and personal barriers resulting in decreased utilization of HIV and STD testing services among at-risk black men who have sex with men in Massachusetts. AIDS Patient Care STDS 23:825-35
Reisner, Sari L; Mimiaga, Matthew J; Skeer, Margie et al. (2009) Clinically significant depressive symptoms as a risk factor for HIV infection among black MSM in Massachusetts. AIDS Behav 13:798-810
Reisner, Sari L; Mimiaga, Matthew J; Bland, Sean et al. (2009) HIV risk and social networks among male-to-female transgender sex workers in Boston, Massachusetts. J Assoc Nurses AIDS Care 20:373-86
Mimiaga, Matthew J; Reisner, Sari L; Cranston, Kevin et al. (2009) Sexual mixing patterns and partner characteristics of black MSM in Massachusetts at increased risk for HIV infection and transmission. J Urban Health 86:602-23
Reisner, Sari L; Mimiaga, Matthew J; Skeer, Margie et al. (2009) A review of HIV antiretroviral adherence and intervention studies among HIV-infected youth. Top HIV Med 17:14-25