Borrelia mayonii is the causative agent of a newly-recognized tick-borne disease. First reported in the upper Midwest during February, 2016, the geographic range of this emerging public health threat is not yet known. Although B. mayonii is related to the classic Lyme disease agent, Borrelia burgdorferi, the two species exhibit substantial genetic differences. We hypothesize that those differences are responsible for the distinct features of B. mayonii infection. A striking difference between the two diseases is the high spirochetemia that has been observed only in patients infected with B. mayonii. Other symptoms of B. mayonii infection include macular rashes across the body, myalgia, and neurological signs, with some patients requiring hospitalization. Three critical questions about B. mayonii and its associated disease are being addressed by our studies: (1) What are the extents of spirochetemia, tissue pathology, and other infectious qualities in untreated mammalian B. mayonii infection? (2) What is responsible for the high-level spirochetemia that occurs during B. mayonii infection, but not during B. burgdorferi infection? and (3) What antigenic proteins are produced during B. mayonii infection, but not during B. burgdorferi infection, that can be used for diagnosis of this emerging disease? Results from our studies will provide valuable insight on the pathogenic properties of B. mayonii and lay important groundwork for diagnosis and treatment.

Public Health Relevance

Borrelia mayonii is a newly-identified tick-borne pathogen of humans in the USA. Symptoms of B. mayonii infection include high-level bacteremia and diffuse macular rashes, which are distinct from those of its relative Borrelia burgdorferi, the Lyme disease agent. The proposed studies focus on elucidating the molecular mechanisms responsible for the unique pathogenic properties of B. mayonii.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Exploratory/Developmental Grants (R21)
Project #
1R21AI129522-01
Application #
9263401
Study Section
Special Emphasis Panel (ZRG1)
Program Officer
Ilias, Maliha R
Project Start
2017-07-24
Project End
2019-06-30
Budget Start
2017-07-24
Budget End
2018-06-30
Support Year
1
Fiscal Year
2017
Total Cost
Indirect Cost
Name
University of Kentucky
Department
Microbiology/Immun/Virology
Type
Schools of Medicine
DUNS #
939017877
City
Lexington
State
KY
Country
United States
Zip Code
40526