The investigator proposes to study the phenotype and function of fine T cell subsets in normal adults, neonatal and pediatric samples, BMT/stem cell transplant patients, chemotherapy/irradiation treated patients, and HIV-infected patients before and after effective anti- viral therapy. The flow cytometry technology available in this lab allows the simultaneous 10-color, 1 parameter analysis of cells that can more clearly identify subsets of T cells and allow the unraveling of the considerable confusion and controversy surrounding the AIDS immunophenotyping literature.
The aims are to determine the parameter that define functionally important T cell subsets, define the functional capacity of the subsets, and study the dynamic equilibrium of the subsets in clinically relevant populations. The data obtained will potentially be useful for elucidating the functional capacity of rare T cell subsets and for the monitoring of T cell reconstitution during anti-viral therapy.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Exploratory/Developmental Grants (R21)
Project #
1R21CA081543-01
Application #
2848397
Study Section
Special Emphasis Panel (ZRG5-AARR-2 (03))
Program Officer
Finerty, John F
Project Start
1998-09-30
Project End
2000-09-29
Budget Start
1998-09-30
Budget End
1999-09-29
Support Year
1
Fiscal Year
1998
Total Cost
Indirect Cost
Name
Stanford University
Department
Genetics
Type
Schools of Medicine
DUNS #
800771545
City
Stanford
State
CA
Country
United States
Zip Code
94305
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