Abstract

The symptoms of insulin-dependent (type I) diabetes could theoretically be corrected by the administration of insulin. Unfortunately, the current method of periodic insulin injection provides a poor approximation of the normal insulin output. Feedback controlled release of insulin into blood circulation is one approach that can be used to maintain blood glucose concentrations at desired levels. This pilot study (R21 application) is aimed at demonstrating the utility of a novel approach to the syntheses of new types of polymeric materials for the development of an artificial pancreas. Specifically, in this application model studies will be performed to build polymeric receptors that can bind the glucose conjugates on such polymeric receptors. If the applicant can successfully demonstrate the feasibility of the concept, it opens the possibility of using the same method for the syntheses of polymeric receptors for glycosylated insulin. Such polymers, if successfully developed, could conceivably be used as an implantable artificial pancreas.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Exploratory/Developmental Grants (R21)
Project #
5R21DK055062-02
Application #
2906349
Study Section
Special Emphasis Panel (ZRG7-SSS-8 (45))
Program Officer
Harmon, Joan T
Project Start
1998-09-30
Project End
2001-09-29
Budget Start
1999-09-30
Budget End
2001-09-29
Support Year
2
Fiscal Year
1999
Total Cost
Indirect Cost

  Institution

Name
North Carolina State University Raleigh
Department
Chemistry
Type
Schools of Arts and Sciences
DUNS #
City
Raleigh
State
NC
Country
United States
Zip Code
27695

  Publications

Jin, Shan; Cheng, Yunfeng; Reid, Suazette et al. (2010) Carbohydrate recognition by boronolectins, small molecules, and lectins. Med Res Rev 30:171-257
Yan, Jun; Fang, Hao; Wang, Binghe (2005) Boronolectins and fluorescent boronolectins: an examination of the detailed chemistry issues important for the design. Med Res Rev 25:490-520
Fang, Hao; Kaur, Gurpreet; Wang, Binghe (2004) Progress in boronic acid-based fluorescent glucose sensors. J Fluoresc 14:481-9
Yang, Wenqian; Fan, Haiying; Gao, Xingming et al. (2004) The first fluorescent diboronic acid sensor specific for hepatocellular carcinoma cells expressing sialyl Lewis X. Chem Biol 11:439-48
Yang, Wenqian; Gao, Xingming; Wang, Binghe (2003) Boronic acid compounds as potential pharmaceutical agents. Med Res Rev 23:346-68
Karnati, Vishnu Vardhan; Gao, Xingming; Gao, Shouhai et al. (2002) A glucose-selective fluorescence sensor based on boronic acid-diol recognition. Bioorg Med Chem Lett 12:3373-7
Yang, Wenqian; Gao, Shouhai; Gao, Xingming et al. (2002) Diboronic acids as fluorescent probes for cells expressing sialyl Lewis X. Bioorg Med Chem Lett 12:2175-7
Ballard, C E; Yu, H; Wang, B (2002) Recent developments in depsipeptide research. Curr Med Chem 9:471-98
Springsteen, G; Ballard, C E; Gao, S et al. (2001) The development of photometric sensors for boronic acids. Bioorg Chem 29:259-70
Gao, S; Wang, W; Wang, B (2001) Building fluorescent sensors for carbohydrates using template-directed polymerizations. Bioorg Chem 29:308-20

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