Abstract

This R21 proposal proposes to systematically sequence 10,000 human adipose expressed sequence tags (ESTs) to 1) obtain a global view of normal adipocyte gene expression, 2) discover novel fat specific or fat abundant genes, and 3) find new functions of known genes and fat tissue.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Exploratory/Developmental Grants (R21)
Project #
5R21DK057835-02
Application #
6381833
Study Section
Metabolism Study Section (MET)
Program Officer
Smith, Philip F
Project Start
2000-05-01
Project End
2003-04-30
Budget Start
2001-05-01
Budget End
2003-04-30
Support Year
2
Fiscal Year
2001
Total Cost
$148,500
Indirect Cost

  Institution

Name
University of Maryland Baltimore
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
003255213
City
Baltimore
State
MD
Country
United States
Zip Code
21201

  Publications

Yang, Rong-Ze; Lee, Mi-Jeong; Hu, Hong et al. (2006) Identification of omentin as a novel depot-specific adipokine in human adipose tissue: possible role in modulating insulin action. Am J Physiol Endocrinol Metab 290:E1253-61
Yang, Rong-Ze; Lee, Mi-Jeong; Hu, Hong et al. (2006) Acute-phase serum amyloid A: an inflammatory adipokine and potential link between obesity and its metabolic complications. PLoS Med 3:e287
Yang, Rong-Ze; Huang, Qing; Xu, Aihua et al. (2003) Comparative studies of resistin expression and phylogenomics in human and mouse. Biochem Biophys Res Commun 310:927-35
Yang, Rong-Ze; Blaileanu, Greorghe; Hansen, Barbara C et al. (2002) cDNA cloning, genomic structure, chromosomal mapping, and functional expression of a novel human alanine aminotransferase. Genomics 79:445-50