The delivery of a therapeutic agent through controlled carriers directly to the tumoral lesion can enhance treatment efficacy by reducing dosage while minimizing systemic circulation of toxic compounds through healthy tissues. As such, the induction of a feedback controlled steering force on ferromagnetic carriers from magnetic gradients generated by an upgraded clinical Magnetic Resonance Imaging (MRI) system has been demonstrated by our group. But the gradient strengths required in some sections of the capillary network surrounding a tumor may be technologically very difficult to achieve for human due mainly to the size and cooling issues of additional gradient coils embedded in the MRI bore. As such, the use of MC-1 Magnetotactic Bacteria (MTB) pushing microbeads with therapeutic agent and nanoparticles to allow real-time tracking with the MRI system of the bacteria may provide complementary means of propulsion in smaller capillaries. More specifically, the aim of this project is to exploit the property of the chain of magnetic single domain nanoparticles (50-100 nm in size) called magnetosomes embedded in each MTB and acting as a navigational compass inside each bacterium combined with the very effective trust provided by the molecular motor of the bacteria to enhance targeting. Navigation control of such bacterial carriers will be performed by changing the direction of the magnetic field under computer control to """"""""migrate"""""""" such bacteria towards the tumoral region. ? ? ?

Agency
National Institute of Health (NIH)
Institute
National Institute of Biomedical Imaging and Bioengineering (NIBIB)
Type
Exploratory/Developmental Grants (R21)
Project #
5R21EB007506-02
Application #
7494144
Study Section
Special Emphasis Panel (ZRG1-BCMB-S (50))
Program Officer
Henderson, Lori
Project Start
2007-09-05
Project End
2010-08-31
Budget Start
2008-09-01
Budget End
2009-08-31
Support Year
2
Fiscal Year
2008
Total Cost
$132,300
Indirect Cost
Name
Ecole Polytechnique de Montreal
Department
Type
DUNS #
250228046
City
Montreal
State
PQ
Country
Canada
Zip Code
Felfoul, Ouajdi; Martel, Sylvain (2013) Assessment of navigation control strategy for magnetotactic bacteria in microchannel: toward targeting solid tumors. Biomed Microdevices 15:1015-24
Mokrani, Nisryn; Felfoul, Ouajdi; Afkhami Zarreh, Fatemeh et al. (2010) Magnetotactic bacteria penetration into multicellular tumor spheroids for targeted therapy. Conf Proc IEEE Eng Med Biol Soc 2010:4371-4
Felfoul, Ouajdi; Mokrani, Nisryn; Mohammadi, Mahmood et al. (2010) Effect of the chain of magnetosomes embedded in magnetotactic bacteria and their motility on magnetic resonance imaging. Conf Proc IEEE Eng Med Biol Soc 2010:4367-70
Martel, Sylvain (2010) Microrobotic navigable entities for Magnetic Resonance Targeting. Conf Proc IEEE Eng Med Biol Soc 2010:1942-5
Martel, Sylvain; Felfoul, Ouajdi; Mathieu, Jean-Baptiste et al. (2009) MRI-based Medical Nanorobotic Platform for the Control of Magnetic Nanoparticles and Flagellated Bacteria for Target Interventions in Human Capillaries. Int J Rob Res 28:1169-1182
Martel, Sylvain; Mohammadi, Mahmood; Felfoul, Ouajdi et al. (2009) Flagellated Magnetotactic Bacteria as Controlled MRI-trackable Propulsion and Steering Systems for Medical Nanorobots Operating in the Human Microvasculature. Int J Rob Res 28:571-582
Martel, Sylvain; Felfoul, Ouajdi; Mohammadi, Mahmood et al. (2008) Interventional procedure based on nanorobots propelled and steered by flagellated magnetotactic bacteria for direct targeting of tumors in the human body. Conf Proc IEEE Eng Med Biol Soc 2008:2497-500
Martel, Sylvain (2008) NANOROBOTS FOR MICROFACTORIES TO OPERATIONS IN THE HUMAN BODY AND ROBOTS PROPELLED BY BACTERIA. Facta Univ Ser Mech Autom Control Robot 7:1-8