New, powerful interventions such as early treatment and pre-exposure prophylaxis are emerging as options for HIV prevention globally. However, their inclusion in HIV prevention strategies at the national level is not warranted, given health systems limitations;and stakeholders'concerns. Moreover, the ways in which such strategies could be incorporated not fixed, and strategic combination prevention programs must be designed. This proposal intends to promote, and study, a process through which (1) HIV prevention stakeholders in Peru can express their views and concerns about existing and emerging (e.g. Pre-Exposure Prophylaxis, Early Treatment for Prevention) HIV prevention interventions focused on MSM/transwomen;(2) the capacity of the health system and changes needed to incorporate emerging interventions, and associated costs, will be assessed;(3) combination prevention scenarios associated with effectiveness and cost-effectiveness estimations will be developed;and (4) stakeholders will seek to agree on one or more feasible and acceptable prevention scenarios, for potential implementation. Methods to be used include stakeholder analysis, health systems and cost assessments, mathematical modeling based on global evidence of effective interventions and on local evidence of stakeholders'views and of health systems conditions, and scenario analysis to discuss proposed scenarios and seek consensus on the most viable one(s) for future implementation.

Public Health Relevance

This proposal intends to promote, and study, a process through which (1) HIV prevention stakeholders in Peru can express their views and concerns about existing and emerging (e.g. Pre-Exposure Prophylaxis, Early Treatment for Prevention) HIV prevention interventions focused on MSM/transwomen;(2) the capacity of the health system and changes needed to incorporate emerging interventions, and associated costs, will be assessed;(3) combination prevention scenarios associated with effectiveness and cost-effectiveness estimations will be developed through mathematical modeling, based on evidence gathered in previous steps;and (4) stakeholders will seek to agree on one or more feasible and acceptable prevention scenarios, for potential implementation.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Exploratory/Developmental Grants (R21)
Project #
5R21MH102135-02
Application #
8733757
Study Section
Behavioral and Social Science Approaches to Preventing HIV/AIDS Study Section (BSPH)
Program Officer
Allison, Susannah
Project Start
2013-09-12
Project End
2015-06-30
Budget Start
2014-07-04
Budget End
2015-06-30
Support Year
2
Fiscal Year
2014
Total Cost
Indirect Cost
Name
Universidad Peruana Cayetano Heredia
Department
Type
DUNS #
City
Lima
State
Country
Peru
Zip Code
LIMA 31
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Chow, Jeremy Y; Konda, Kelika A; Borquez, Annick et al. (2016) Peru's HIV care continuum among men who have sex with men and transgender women: opportunities to optimize treatment and prevention. Int J STD AIDS 27:1039-1048
Cáceres, Carlos F; Koechlin, Florence; Goicochea, Pedro et al. (2015) The promises and challenges of pre-exposure prophylaxis as part of the emerging paradigm of combination HIV prevention. J Int AIDS Soc 18:19949
Cáceres, Carlos F; O'Reilly, Kevin R; Mayer, Kenneth H et al. (2015) PrEP implementation: moving from trials to policy and practice. J Int AIDS Soc 18:20222
Cáceres, Carlos F; Mayer, Kenneth H; Baggaley, Rachel et al. (2015) PrEP Implementation Science: State-of-the-Art and Research Agenda. J Int AIDS Soc 18:20527
Paiva, Vera; Ferguson, Laura; Aggleton, Peter et al. (2015) The current state of play of research on the social, political and legal dimensions of HIV. Cad Saude Publica 31:477-86
Cáceres, Carlos F (2015) A HOPE for HIV prevention in virtual MSM communities. Lancet HIV 2:e6-7
Lee, Sky W; Deiss, Robert G; Segura, Eddy R et al. (2015) A cross-sectional study of low HIV testing frequency and high-risk behaviour among men who have sex with men and transgender women in Lima, Peru. BMC Public Health 15:408