This proposal applies novel engineering approaches to the problems of low vision rehabilitation. We shall do this by building prototype devices based on solid theoretical foundations that, eventually, will become marketable rehabilitation products. The devices, designed and built with the help of our engineering partners, will be tested critically using diverse patient populations, with the help of the clinical partners to determine the effects on function and on the quality of life. We shall develop and test both optical and electronic devices that implement three specific engineering approaches aimed at restoring (at least in part) the important interplay of central (high-resolution) and peripheral (wide-field) vision. The three engineering approaches that we will explore are multiplexing dynamic control of display, and image enhancement. Also, we show that various combinations of these approaches are possible and likely to be beneficial. In our proposed assessment and testing we emphasize two approaches: a virtual environment for controlled and quantitative testing in the laboratory, and on-the-street evaluation for real-life determination of the effect and usefulness of the devices and techniques.
| Vera-Diaz, Fuensanta A; Woods, Russell L; Peli, Eli (2017) Blur Adaptation to Central Retinal Disease. Invest Ophthalmol Vis Sci 58:3646-3655 |
| Bronstad, P Matthew; Albu, Amanda; Goldstein, Robert et al. (2016) Driving with central field loss III: vehicle control. Clin Exp Optom 99:435-40 |
| Shen, Jieming; Peli, Eli; Bowers, Alex R (2015) Peripheral prism glasses: effects of moving and stationary backgrounds. Optom Vis Sci 92:412-20 |
| Bronstad, P Matthew; Albu, Amanda; Bowers, Alex R et al. (2015) Driving with Central Visual Field Loss II: How Scotomas above or below the Preferred Retinal Locus (PRL) Affect Hazard Detection in a Driving Simulator. PLoS One 10:e0136517 |
| Sayegh, Rony R; Dohlman, Claes H; Greenstein, Scott H et al. (2015) The Boston keratoprosthesis provides a wide depth of focus. Ophthalmic Physiol Opt 35:39-44 |
| Alberti, Concetta F; Peli, Eli; Bowers, Alex R (2014) Driving with hemianopia: III. Detection of stationary and approaching pedestrians in a simulator. Invest Ophthalmol Vis Sci 55:368-74 |
| Alberti, Concetta F; Horowitz, Todd; Bronstad, P Matthew et al. (2014) Visual attention measures predict pedestrian detection in central field loss: a pilot study. PLoS One 9:e89381 |
| Bowers, Alex R; Ananyev, Egor; Mandel, Aaron J et al. (2014) Driving with hemianopia: IV. Head scanning and detection at intersections in a simulator. Invest Ophthalmol Vis Sci 55:1540-8 |
| Bowers, Alex R; Keeney, Karen; Peli, Eli (2014) Randomized crossover clinical trial of real and sham peripheral prism glasses for hemianopia. JAMA Ophthalmol 132:214-22 |
| Bronstad, P Matthew; Bowers, Alex R; Albu, Amanda et al. (2013) Driving with central field loss I: effect of central scotomas on responses to hazards. JAMA Ophthalmol 131:303-9 |
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