This proposal applies novel engineering approaches to the problems of low vision rehabilitation. We shall do this by building prototype devices based on solid theoretical foundations that, eventually, will become marketable rehabilitation products. The devices, designed and built with the help of our engineering partners, will be tested critically using diverse patient populations, with the help of the clinical partners to determine the effects on function and on the quality of life. We shall develop and test both optical and electronic devices that implement three specific engineering approaches aimed at restoring (at least in part) the important interplay of central (high-resolution) and peripheral (wide-field) vision. The three engineering approaches that we will explore are multiplexing dynamic control of display, and image enhancement. Also, we show that various combinations of these approaches are possible and likely to be beneficial. In our proposed assessment and testing we emphasize two approaches: a virtual environment for controlled and quantitative testing in the laboratory, and on-the-street evaluation for real-life determination of the effect and usefulness of the devices and techniques.

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Resource-Related Research Projects (R24)
Project #
3R24EY012890-05S2
Application #
7121313
Study Section
Special Emphasis Panel (ZRG1)
Program Officer
Oberdorfer, Michael
Project Start
2000-09-30
Project End
2006-09-29
Budget Start
2004-09-30
Budget End
2006-09-29
Support Year
5
Fiscal Year
2005
Total Cost
$1,016,193
Indirect Cost
Name
Schepens Eye Research Institute
Department
Type
DUNS #
073826000
City
Boston
State
MA
Country
United States
Zip Code
02114
Vera-Diaz, Fuensanta A; Woods, Russell L; Peli, Eli (2017) Blur Adaptation to Central Retinal Disease. Invest Ophthalmol Vis Sci 58:3646-3655
Bronstad, P Matthew; Albu, Amanda; Goldstein, Robert et al. (2016) Driving with central field loss III: vehicle control. Clin Exp Optom 99:435-40
Shen, Jieming; Peli, Eli; Bowers, Alex R (2015) Peripheral prism glasses: effects of moving and stationary backgrounds. Optom Vis Sci 92:412-20
Bronstad, P Matthew; Albu, Amanda; Bowers, Alex R et al. (2015) Driving with Central Visual Field Loss II: How Scotomas above or below the Preferred Retinal Locus (PRL) Affect Hazard Detection in a Driving Simulator. PLoS One 10:e0136517
Sayegh, Rony R; Dohlman, Claes H; Greenstein, Scott H et al. (2015) The Boston keratoprosthesis provides a wide depth of focus. Ophthalmic Physiol Opt 35:39-44
Alberti, Concetta F; Peli, Eli; Bowers, Alex R (2014) Driving with hemianopia: III. Detection of stationary and approaching pedestrians in a simulator. Invest Ophthalmol Vis Sci 55:368-74
Alberti, Concetta F; Horowitz, Todd; Bronstad, P Matthew et al. (2014) Visual attention measures predict pedestrian detection in central field loss: a pilot study. PLoS One 9:e89381
Bowers, Alex R; Ananyev, Egor; Mandel, Aaron J et al. (2014) Driving with hemianopia: IV. Head scanning and detection at intersections in a simulator. Invest Ophthalmol Vis Sci 55:1540-8
Bowers, Alex R; Keeney, Karen; Peli, Eli (2014) Randomized crossover clinical trial of real and sham peripheral prism glasses for hemianopia. JAMA Ophthalmol 132:214-22
Apfelbaum, Henry L; Ross, Nicole C; Bowers, Alex R et al. (2013) Considering Apical Scotomas, Confusion, and Diplopia When Prescribing Prisms for Homonymous Hemianopia. Transl Vis Sci Technol 2:2

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