The goal is to develop a comprehensive genetic management strategy for the chimpanzee breeding program at the U.T. Veterinary Resources Division, Bastrop, Texas, and to extend the study to include chimpanzee breeding programs at LEMSIP, N.Y. University School of Medicine and the Primate Foundation of Arizona. This goal will be accomplished by achieving the following Specific Aims. 1) To establish the paternity of all offspring for whom the mother and potential fathers are living, using highly polymorphic DNA sequences that will uniquely distinguish each mating; 2) to utilize the mother-offspring data and paternity results to construct a complete genealogy of the population; 3) to determine the phenotypes of all animals at a large number of discrete genetic loci, to map these data on the genealogies for use in specific genetic studies of physiological, medical and behavioral traits, and to use these data to identify genetic loci affecting reproduction; 4) to set up an accessible, computerized data base consisting of all genealogical, genetic, historical and demographic data for use in genetic management of the breeding program and as a resource to support long term genetic studies of the population. The genetic characterization of the population will utilize a variety of highly polymorphic DNA probes and single copy c-DNA sequences, erythrocyte antigens and plasma and erythrocyte proteins. These studies will contribute to the goal of optimum utilization and management of the chimpanzee as a model for human health and disease.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Resource-Related Research Projects (R24)
Project #
5R24RR003577-04
Application #
3450824
Study Section
(SRC)
Project Start
1986-09-30
Project End
1991-09-29
Budget Start
1989-09-30
Budget End
1991-09-29
Support Year
4
Fiscal Year
1989
Total Cost
Indirect Cost
Name
University of Pittsburgh
Department
Type
Schools of Public Health
DUNS #
053785812
City
Pittsburgh
State
PA
Country
United States
Zip Code
15213
Kamboh, M I; Kelly, L J; Ahn, Y I et al. (1994) Genetic polymorphism of apolipoprotein A-IV in the chimpanzee: common deletion of a conserved 12-nucleotide tandem repeat. Hum Biol 66:625-38
Ely, J; Deka, R; Chakraborty, R et al. (1992) Comparison of five tandem repeat loci between humans and chimpanzees. Genomics 14:692-8
Kamboh, M I; Ferrell, R E (1987) Genetic studies of human apolipoproteins. I. Polymorphism of apolipoprotein A-IV. Am J Hum Genet 41:119-27