Three decades of psychobiological research with rodents, nonhuman primates, and humans have documented the existence of individual differences in temperament, emotionality, behavioral and physiological reactivity, and personality, which we refer to as biobehavioral organization. These characteristics influence an individual's style of adaptation to its environment, and evidence shows that the quality of the animal's adaptations is associated with indices of psychological and physical health. At the California National Primate Research Center, we have developed a program to assess biobehavioral organization in infant rhesus monkeys. Our protocol includes a) collecting behavioral data in several situations designed to assess memory, responsiveness to mild challenges, and willingness to interact with novel objects;b) genotyping for polymorphisms in the promoter regions of two neuropsychiatric genes, the serotonin transporter and monoamine oxidase-A;c) assessing regulation of the hypothalamic-pituitary-adrenal system;and d) measuring routine hematologic parameters. Data from this resource are available to all CNPRC service and scientific staff via a web interface, to use for scientific and colony management purposes. In the current application, we propose the following specific aims: to continue performing our BioBehavioral Assessment on approximately 300 infant rhesus monkeys per year and to make these data available to qualified scientific and management staff through our web page as soon as the processing of the data is complete each year;to continue our ongoing efforts to identify the attributes of former participants in our BBA program that are at risk for poor adaptation to a captive environment as indexed by measures of chronic illness, abnormal behaviors, poor reproduction, and aberrant social function;to use existing statistical methods on our BBA data to establish individual profiles associated with poor outcomes as aids to colony management personnel to prevent health, behavioral, reproductive, and social problems;to continue to develop standardized tests that are shorter, simpler, and easier to administer than our current procedure, yet meet the same standards of reliability and predictive validity for our outcome measures.

Public Health Relevance

(provided by applicant): This project will result in improved nonhuman primate models for health-related research, and will provide a database that will be uniquely able to contribute to the development of primate models of personalized medicine.

National Institute of Health (NIH)
National Center for Research Resources (NCRR)
Resource-Related Research Projects (R24)
Project #
Application #
Study Section
National Center for Research Resources Initial Review Group (RIRG)
Program Officer
Watson, William T
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of California Davis
Veterinary Sciences
Other Domestic Higher Education
United States
Zip Code
Pittet, Florent; Johnson, Crystal; Hinde, Katie (2017) Age at reproductive debut: Developmental predictors and consequences for lactation, infant mass, and subsequent reproduction in rhesus macaques (Macaca mulatta). Am J Phys Anthropol 164:457-476
Su, Shu-Yi; Hogrefe-Phi, Casey E; Asara, John M et al. (2016) Peripheral fibroblast metabolic pathway alterations in juvenile rhesus monkeys undergoing long-term fluoxetine administration. Eur Neuropsychopharmacol 26:1110-8
Bernstein, Robin M; Hinde, Katie (2016) Bioactive factors in milk across lactation: Maternal effects and influence on infant growth in rhesus macaques (Macaca mulatta). Am J Primatol 78:838-50
Golub, Mari S; Hogrefe, Casey E (2015) Fetal iron deficiency and genotype influence emotionality in infant rhesus monkeys. J Nutr 145:647-53
Golub, Mari S; Bulleri, Alicia M; Hogrefe, Casey E et al. (2015) Bone growth in juvenile rhesus monkeys is influenced by 5HTTLPR polymorphisms and interactions between 5HTTLPR polymorphisms and fluoxetine. Bone 79:162-9
Weinstein, Tamara A R; Bales, Karen L; Maninger, Nicole et al. (2014) Early involvement in friendships predicts later plasma concentrations of oxytocin and vasopressin in juvenile rhesus macaques (Macaca mulatta). Front Behav Neurosci 8:295
Golub, Mari S; Hogrefe, Casey E (2014) Sleep patterns in male juvenile monkeys are influenced by gestational iron deprivation and monoamine oxidase A genotype. Br J Nutr 112:1478-83
Bauman, Melissa D; Iosif, Ana-Maria; Smith, Stephen E P et al. (2014) Activation of the maternal immune system during pregnancy alters behavioral development of rhesus monkey offspring. Biol Psychiatry 75:332-41
Chun, Katie; Miller, Lisa A; Schelegle, Edward S et al. (2013) Behavioral inhibition in rhesus monkeys (Macaca mulatta) is related to the airways response, but not immune measures, commonly associated with asthma. PLoS One 8:e71575
Gottlieb, Daniel H; Capitanio, John P (2013) Latent variables affecting behavioral response to the human intruder test in infant rhesus macaques (Macaca mulatta). Am J Primatol 75:314-23

Showing the most recent 10 out of 35 publications