Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
First Independent Research Support & Transition (FIRST) Awards (R29)
Project #
5R29AI037637-02
Application #
2074466
Study Section
Pathology A Study Section (PTHA)
Project Start
1995-03-15
Project End
2000-02-29
Budget Start
1996-03-01
Budget End
1997-02-28
Support Year
2
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Weill Medical College of Cornell University
Department
Biochemistry
Type
Schools of Medicine
DUNS #
201373169
City
New York
State
NY
Country
United States
Zip Code
10065
Deora, A A; Hajjar, D P; Lander, H M (2000) Recruitment and activation of Raf-1 kinase by nitric oxide-activated Ras. Biochemistry 39:9901-8
Sehajpal, P K; Basu, A; Ogiste, J S et al. (1999) Reversible S-nitrosation and inhibition of HIV-1 protease. Biochemistry 38:13407-13
Deora, A A; Win, T; Vanhaesebroeck, B et al. (1998) A redox-triggered ras-effector interaction. Recruitment of phosphatidylinositol 3'-kinase to Ras by redox stress. J Biol Chem 273:29923-8
Seyedi, N; Win, T; Lander, H M et al. (1997) Bradykinin B2-receptor activation augments norepinephrine exocytosis from cardiac sympathetic nerve endings. Mediation by autocrine/paracrine mechanisms. Circ Res 81:774-84
Lander, H M; Hajjar, D P; Hempstead, B L et al. (1997) A molecular redox switch on p21(ras). Structural basis for the nitric oxide-p21(ras) interaction. J Biol Chem 272:4323-6
Lander, H M (1997) An essential role for free radicals and derived species in signal transduction. FASEB J 11:118-24
Pomerantz, K B; Lander, H M; Summers, B et al. (1997) G-protein-mediated signaling in cholesterol-enriched arterial smooth muscle cells. 2. Role of protein kinase C-delta in the regulation of eicosanoid production. Biochemistry 36:9532-9
Lander, H M; Tauras, J M; Ogiste, J S et al. (1997) Activation of the receptor for advanced glycation end products triggers a p21(ras)-dependent mitogen-activated protein kinase pathway regulated by oxidant stress. J Biol Chem 272:17810-4
Pomerantz, K B; Lander, H M; Summers, B et al. (1997) G-protein-mediated signaling in cholesterol-enriched arterial smooth muscle cells. 1. Reduced membrane-associated G-protein content due to diminished isoprenylation of G-gamma subunits and p21ras. Biochemistry 36:9523-31
Lander, H M; Jacovina, A T; Davis, R J et al. (1996) Differential activation of mitogen-activated protein kinases by nitric oxide-related species. J Biol Chem 271:19705-9

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