Agency
National Institute of Health (NIH)
Institute
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Type
First Independent Research Support & Transition (FIRST) Awards (R29)
Project #
5R29AR040253-05
Application #
2079942
Study Section
Orthopedics and Musculoskeletal Study Section (ORTH)
Project Start
1990-03-01
Project End
1995-12-31
Budget Start
1994-03-01
Budget End
1995-12-31
Support Year
5
Fiscal Year
1994
Total Cost
Indirect Cost
Name
Hospital for Special Surgery
Department
Type
DUNS #
City
New York
State
NY
Country
United States
Zip Code
10021
Rapuano, B E; Bockman, R S (1998) Activators of protein kinase A decrease the levels of free arachidonic acid in osteoblasts via stimulation of phosphatidylcholine and phosphatidylethanolamine synthesis. Prostaglandins Leukot Essent Fatty Acids 58:147-56
Rapuano, B E; Bockman, R S (1997) Protein kinase C-independent activation of a novel nonspecific phospholipase C pathway by phorbol myristate acetate releases arachidonic acid for prostaglandin synthesis in MC3T3-E1 osteoblasts. Prostaglandins 53:163-86
Rapuano, B E; Bockman, R S (1997) Protein kinases A and C positively regulate G protein-dependent activation of phosphatidylinositol-specific phospholipase C by tumor necrosis factor-alpha in MC3T3-E1 osteoblasts. J Cell Biochem 65:198-208
Suzuki, K; Rapuano, B E; Bockman, R S (1997) Role of protein kinase A in collagenase-1 gene regulation by prostaglandin E1: studies in a rabbit synoviocyte cell line, HIG-82. J Bone Miner Res 12:561-7
Rapuano, B E; Bockman, R S (1994) Pertussis toxin-sensitive and insensitive G proteins mediate ALFL4- stimulated release of inositol phosphates, diglycerides and arachidonic acid in MC3T3-E1 osteoblasts. Prostaglandins Leukot Essent Fatty Acids 50:177-81
Guidon Jr, P T; Salvatori, R; Bockman, R S (1993) Gallium nitrate regulates rat osteoblast expression of osteocalcin protein and mRNA levels. J Bone Miner Res 8:103-12
Salvatori, R; Guidon Jr, P T; Rapuano, B E et al. (1992) Prostaglandin E1 inhibits collagenase gene expression in rabbit synoviocytes and human fibroblasts. Endocrinology 131:21-8