Agency
National Institute of Health (NIH)
Institute
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Type
First Independent Research Support & Transition (FIRST) Awards (R29)
Project #
5R29AR040580-05
Application #
2080135
Study Section
Cardiovascular and Pulmonary Research A Study Section (CVA)
Project Start
1991-04-01
Project End
1996-09-30
Budget Start
1995-04-01
Budget End
1996-09-30
Support Year
5
Fiscal Year
1995
Total Cost
Indirect Cost
Name
St. Elizabeth's Medical Center of Boston
Department
Type
DUNS #
073797292
City
Boston
State
MA
Country
United States
Zip Code
01235
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Takeshita, S; Gal, D; Leclerc, G et al. (1994) Increased gene expression after liposome-mediated arterial gene transfer associated with intimal smooth muscle cell proliferation. In vitro and in vivo findings in a rabbit model of vascular injury. J Clin Invest 93:652-61
Losordo, D W; Pickering, J G; Takeshita, S et al. (1994) Use of the rabbit ear artery to serially assess foreign protein secretion after site-specific arterial gene transfer in vivo. Evidence that anatomic identification of successful gene transfer may underestimate the potential magnitude of transgene expressi Circulation 89:785-92
Pickering, J G; Bacha, P A; Weir, L et al. (1993) Prevention of smooth muscle cell outgrowth from human atherosclerotic plaque by a recombinant cytotoxin specific for the epidermal growth factor receptor. J Clin Invest 91:724-9
Pickering, J G; Weir, L; Jekanowski, J et al. (1993) Proliferative activity in peripheral and coronary atherosclerotic plaque among patients undergoing percutaneous revascularization. J Clin Invest 91:1469-80
Gal, D; Weir, L; Leclerc, G et al. (1993) Direct myocardial transfection in two animal models. Evaluation of parameters affecting gene expression and percutaneous gene delivery. Lab Invest 68:18-25
Leclerc, G; Gal, D; Takeshita, S et al. (1992) Percutaneous arterial gene transfer in a rabbit model. Efficiency in normal and balloon-dilated atherosclerotic arteries. J Clin Invest 90:936-44
Nikol, S; Isner, J M; Pickering, J G et al. (1992) Expression of transforming growth factor-beta 1 is increased in human vascular restenosis lesions. J Clin Invest 90:1582-92
Pickering, J G; Weir, L; Rosenfield, K et al. (1992) Smooth muscle cell outgrowth from human atherosclerotic plaque: implications for the assessment of lesion biology. J Am Coll Cardiol 20:1430-9
Leclerc, G; Isner, J M; Kearney, M et al. (1992) Evidence implicating nonmuscle myosin in restenosis. Use of in situ hybridization to analyze human vascular lesions obtained by directional atherectomy. Circulation 85:543-53