Abstract

Aseptic loosening continues to be a problem with total hip replacements. In cemented total hip replacement, mechanically induced loosening most often initiates at the stem-cement or cement-bone interface. And while it is widely accepted that a strong bone is desirable at the cement-bone interface, the optimal cement-metal interface is disputed for cemented femoral components. A research program is proposed to investigate: 1) the specific mechanical conditions under which the femoral stem-cement and cement-bone interfaces fail; 2) the manner in which interface failure contributes to mechanical loosening of cemented femoral hip components; and 3) the use of this information to """"""""optimize"""""""" the locations and extent of stem-cement bonding to reduce the risk of implant failure. Here, """"""""bonding"""""""" is used to describe any enhanced stem-cement interface (mechanically roughened or PMMA precoated), as compared to a smooth unbonded interface. It is the hypothesis of this work that the manner and extent of bonding of the stem-cement interface affects the overall failure (loosening) of the implant. It is further hypothesized that some """"""""optimum"""""""" configuration, consisting of regions where the stem is bonded, and regions where the stem is unbonded, will result in a significant increase in the long-term performance of the implant.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Type
First Independent Research Support & Transition (FIRST) Awards (R29)
Project #
5R29AR042017-03
Application #
2732852
Study Section
Orthopedics and Musculoskeletal Study Section (ORTH)
Project Start
1996-07-15
Project End
1999-06-30
Budget Start
1998-07-01
Budget End
1999-06-30
Support Year
3
Fiscal Year
1998
Total Cost
Indirect Cost

  Institution

Name
University of Alabama Birmingham
Department
Biomedical Engineering
Type
Schools of Engineering
DUNS #
004514360
City
Birmingham
State
AL
Country
United States
Zip Code
35294

  Publications

Srinivasan, Priyanka; Miller, Mark A; Verdonschot, Nico et al. (2017) A modelling approach demonstrating micromechanical changes in the tibial cemented interface due to in vivo service. J Biomech 56:19-25
Srinivasan, Priyanka; Miller, Mark A; Verdonschot, Nico et al. (2017) Strain shielding in trabecular bone at the tibial cement-bone interface. J Mech Behav Biomed Mater 66:181-186
Srinivasan, Priyanka; Miller, Mark A; Verdonschot, Nico et al. (2016) Experimental and computational micromechanics at the tibial cement-trabeculae interface. J Biomech 49:1641-1648
Zimmerman, William F; Miller, Mark A; Cleary, Richard J et al. (2016) Damage in total knee replacements from mechanical overload. J Biomech 49:2068-2075
Miller, Mark A; Goodheart, Jacklyn R; Khechen, Benjamin et al. (2016) Changes in microgaps, micromotion, and trabecular strain from interlocked cement-trabecular bone interfaces in total knee replacements with in vivo service. J Orthop Res 34:1019-25
Mann, Kenneth A; Miller, Mark A; Goodheart, Jacklyn R et al. (2014) Peri-implant bone strains and micro-motion following in vivo service: a postmortem retrieval study of 22 tibial components from total knee replacements. J Orthop Res 32:355-61
Mann, Kenneth A; Miller, Mark A (2014) Fluid-structure interactions in micro-interlocked regions of the cement-bone interface. Comput Methods Biomech Biomed Engin 17:1809-20
Miller, Mark A; Terbush, Matthew J; Goodheart, Jacklyn R et al. (2014) Increased initial cement-bone interlock correlates with reduced total knee arthroplasty micro-motion following in vivo service. J Biomech 47:2460-6
Miller, Mark A; Goodheart, Jacklyn R; Izant, Timothy H et al. (2014) Loss of cement-bone interlock in retrieved tibial components from total knee arthroplasties. Clin Orthop Relat Res 472:304-13
Howard, Karen I; Miller, Mark A; Damron, Timothy A et al. (2014) The distribution of implant fixation for femoral components of TKA: a postmortem retrieval study. J Arthroplasty 29:1863-70

Showing the most recent 10 out of 32 publications