Agency
National Institute of Health (NIH)
Institute
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Type
First Independent Research Support & Transition (FIRST) Awards (R29)
Project #
1R29AR043732-01A1
Application #
2083479
Study Section
Orthopedics and Musculoskeletal Study Section (ORTH)
Project Start
1996-07-10
Project End
2001-06-30
Budget Start
1996-07-10
Budget End
1997-06-30
Support Year
1
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Pennsylvania
Department
Anatomy/Cell Biology
Type
Schools of Dentistry
DUNS #
042250712
City
Philadelphia
State
PA
Country
United States
Zip Code
19104
Wang, Wei; Xu, Jinping; Kirsch, Thorsten (2003) Annexin-mediated Ca2+ influx regulates growth plate chondrocyte maturation and apoptosis. J Biol Chem 278:3762-9
Wang, Wei; Kirsch, Thorsten (2002) Retinoic acid stimulates annexin-mediated growth plate chondrocyte mineralization. J Cell Biol 157:1061-9
D'Angelo, M; Billings, P C; Pacifici, M et al. (2001) Authentic matrix vesicles contain active metalloproteases (MMP). a role for matrix vesicle-associated MMP-13 in activation of transforming growth factor-beta. J Biol Chem 276:11347-53
Nah, H D; Swoboda, B; Birk, D E et al. (2001) Type IIA procollagen: expression in developing chicken limb cartilage and human osteoarthritic articular cartilage. Dev Dyn 220:307-22
Pfander, D; Swoboda, B; Kirsch, T (2001) Expression of early and late differentiation markers (proliferating cell nuclear antigen, syndecan-3, annexin VI, and alkaline phosphatase) by human osteoarthritic chondrocytes. Am J Pathol 159:1777-83
Kirsch, T; Harrison, G; Golub, E E et al. (2000) The roles of annexins and types II and X collagen in matrix vesicle-mediated mineralization of growth plate cartilage. J Biol Chem 275:35577-83
Kirsch, T; Claassen, H (2000) Matrix vesicles mediate mineralization of human thyroid cartilage. Calcif Tissue Int 66:292-7
Kirsch, T; Swoboda, B; Nah, H (2000) Activation of annexin II and V expression, terminal differentiation, mineralization and apoptosis in human osteoarthritic cartilage. Osteoarthritis Cartilage 8:294-302
Kirsch, T; Harrison, G; Worch, K P et al. (2000) Regulatory roles of zinc in matrix vesicle-mediated mineralization of growth plate cartilage. J Bone Miner Res 15:261-70
Kirsch, T; Nah, H D; Shapiro, I M et al. (1997) Regulated production of mineralization-competent matrix vesicles in hypertrophic chondrocytes. J Cell Biol 137:1149-60

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