Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
First Independent Research Support & Transition (FIRST) Awards (R29)
Project #
7R29CA063139-03
Application #
2104808
Study Section
Pathology B Study Section (PTHB)
Project Start
1994-06-01
Project End
1999-05-31
Budget Start
1996-03-25
Budget End
1996-05-31
Support Year
3
Fiscal Year
1995
Total Cost
Indirect Cost
Name
Indiana University-Purdue University at Indianapolis
Department
Biochemistry
Type
Schools of Medicine
DUNS #
005436803
City
Indianapolis
State
IN
Country
United States
Zip Code
46202
Reuther, G W; Buss, J E; Quilliam, L A et al. (2000) Analysis of function and regulation of proteins that mediate signal transduction by use of lipid-modified plasma membrane-targeting sequences. Methods Enzymol 327:331-50
Rebhun, J F; Chen, H; Quilliam, L A (2000) Identification and characterization of a new family of guanine nucleotide exchange factors for the ras-related GTPase Ral. J Biol Chem 275:13406-10
Quilliam, L A; Castro, A F; Rogers-Graham, K S et al. (1999) M-Ras/R-Ras3, a transforming ras protein regulated by Sos1, GRF1, and p120 Ras GTPase-activating protein, interacts with the putative Ras effector AF6. J Biol Chem 274:23850-7
Braverman, L E; Quilliam, L A (1999) Identification of Grb4/Nckbeta, a src homology 2 and 3 domain-containing adapter protein having similar binding and biological properties to Nck. J Biol Chem 274:5542-9
Quilliam, L A; Hisaka, M M; Zhong, S et al. (1996) Involvement of the switch 2 domain of Ras in its interaction with guanine nucleotide exchange factors. J Biol Chem 271:11076-82
Bokoch, G M; Wang, Y; Bohl, B P et al. (1996) Interaction of the Nck adapter protein with p21-activated kinase (PAK1). J Biol Chem 271:25746-9
Quilliam, L A; Lambert, Q T; Mickelson-Young, L A et al. (1996) Isolation of a NCK-associated kinase, PRK2, an SH3-binding protein and potential effector of Rho protein signaling. J Biol Chem 271:28772-6
Song, K S; Li Shengwen; Okamoto, T et al. (1996) Co-purification and direct interaction of Ras with caveolin, an integral membrane protein of caveolae microdomains. Detergent-free purification of caveolae microdomains. J Biol Chem 271:9690-7
Quilliam, L A; Khosravi-Far, R; Huff, S Y et al. (1995) Guanine nucleotide exchange factors: activators of the Ras superfamily of proteins. Bioessays 17:395-404
Hauser, C A; Westwick, J K; Quilliam, L A (1995) Ras-mediated transcription activation: analysis by transient cotransfection assays. Methods Enzymol 255:412-26