Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
First Independent Research Support & Transition (FIRST) Awards (R29)
Project #
5R29CA065892-02
Application #
2109073
Study Section
Cellular Biology and Physiology Subcommittee 1 (CBY)
Project Start
1994-12-09
Project End
1999-11-30
Budget Start
1995-12-01
Budget End
1996-11-30
Support Year
2
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Wistar Institute
Department
Type
DUNS #
042250712
City
Philadelphia
State
PA
Country
United States
Zip Code
19104
Liu, A x; Du, W; Liu, J P et al. (2000) RhoB alteration is necessary for apoptotic and antineoplastic responses to farnesyltransferase inhibitors. Mol Cell Biol 20:6105-13
Du, W; Lebowitz, P F; Prendergast, G C (1999) Elevation of alpha2(I) collagen, a suppressor of Ras transformation, is required for stable phenotypic reversion by farnesyltransferase inhibitors. Cancer Res 59:2059-63
Du, W; Liu, A; Prendergast, G C (1999) Activation of the PI3'K-AKT pathway masks the proapoptotic effects of farnesyltransferase inhibitors. Cancer Res 59:4208-12
Du, W; Lebowitz, P F; Prendergast, G C (1999) Cell growth inhibition by farnesyltransferase inhibitors is mediated by gain of geranylgeranylated RhoB. Mol Cell Biol 19:1831-40
Du, W; Prendergast, G C (1999) Geranylgeranylated RhoB mediates suppression of human tumor cell growth by farnesyltransferase inhibitors. Cancer Res 59:5492-6
Basu, A; Rodeck, U; Prendergast, G C et al. (1999) Loss of insulin-like growth factor I receptor-dependent expression of p107 and cyclin A in cells that lack the extracellular matrix protein secreted protein acidic and rich in cysteine. Cell Growth Differ 10:721-8
Lebowitz, P F; Prendergast, G C (1998) Functional interaction between RhoB and the transcription factor DB1. Cell Adhes Commun 6:277-87
Lebowitz, P F; Casey, P J; Prendergast, G C et al. (1997) Farnesyltransferase inhibitors alter the prenylation and growth-stimulating function of RhoB. J Biol Chem 272:15591-4
Lebowitz, P F; Du, W; Prendergast, G C (1997) Prenylation of RhoB is required for its cell transforming function but not its ability to activate serum response element-dependent transcription. J Biol Chem 272:16093-5
Lebowitz, P F; Sakamuro, D; Prendergast, G C (1997) Farnesyl transferase inhibitors induce apoptosis of Ras-transformed cells denied substratum attachment. Cancer Res 57:708-13

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