In this proposal, it is proposed to develop ART: a closed loop feedback process where the treatment is optimized on the basis of individual patient variation data obtained during the course of treatment. This goal will be accomplished through three specific aims: 1) Derive a model to predict the time-course of individual patent treatment variation, 2) Implement feedback of the information from the predictive model into a treatment planning system that will compensate for the variation, 3) Perform preliminary clinical studies of ART.

National Institute of Health (NIH)
National Cancer Institute (NCI)
First Independent Research Support & Transition (FIRST) Awards (R29)
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Radiation Study Section (RAD)
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Stone, Helen B
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William Beaumont Hospital
Royal Oak
United States
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Ghilezan, Michel; Yan, Di; Martinez, Alvaro (2010) Adaptive radiation therapy for prostate cancer. Semin Radiat Oncol 20:130-7
Nuyttens, Joost J; Robertson, John M; Yan, Di et al. (2004) The influence of small bowel motion on both a conventional three-field and intensity modulated radiation therapy (IMRT) for rectal cancer. Cancer Radiother 8:297-304
Birkner, M; Yan, D; Alber, M et al. (2003) Adapting inverse planning to patient and organ geometrical variation: algorithm and implementation. Med Phys 30:2822-31
Deasy, Joseph O; Niemierko, Andrzej; Herbert, Donald et al. (2002) Methodological issues in radiation dose-volume outcome analyses: summary of a joint AAPM/NIH workshop. Med Phys 29:2109-27
Nuyttens, Joost J; Robertson, John M; Yan, Di et al. (2002) The variability of the clinical target volume for rectal cancer due to internal organ motion during adjuvant treatment. Int J Radiat Oncol Biol Phys 53:497-503
Nuyttens, J J; Robertson, J M; Yan, D et al. (2001) The position and volume of the small bowel during adjuvant radiation therapy for rectal cancer. Int J Radiat Oncol Biol Phys 51:1271-80
Martinez, A A; Yan, D; Lockman, D et al. (2001) Improvement in dose escalation using the process of adaptive radiotherapy combined with three-dimensional conformal or intensity-modulated beams for prostate cancer. Int J Radiat Oncol Biol Phys 50:1226-34
Yan, D; Lockman, D (2001) Organ/patient geometric variation in external beam radiotherapy and its effects. Med Phys 28:593-602
Yan, D; Lockman, D; Brabbins, D et al. (2000) An off-line strategy for constructing a patient-specific planning target volume in adaptive treatment process for prostate cancer. Int J Radiat Oncol Biol Phys 48:289-302
Lockman, D M; Yan, D; Wong, J (2000) Estimating the dose variation in a volume of interest with explicit consideration of patient geometric variation. Med Phys 27:2100-8

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