Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
First Independent Research Support & Transition (FIRST) Awards (R29)
Project #
5R29DA008647-03
Application #
2013181
Study Section
Drug Abuse Biomedical Research Review Committee (DABR)
Project Start
1994-09-30
Project End
1999-08-31
Budget Start
1996-09-30
Budget End
1997-08-31
Support Year
3
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Organix, Inc.
Department
Type
DUNS #
City
Woburn
State
MA
Country
United States
Zip Code
01801
Dutta, Aloke K; Zhang, Shijun; Kolhatkar, Rohit et al. (2003) Dopamine transporter as target for drug development of cocaine dependence medications. Eur J Pharmacol 479:93-106
Dutta, A K; Fei, X S; Vaughan, R A et al. (2001) Design, synthesis, and characterization of a novel, 4-[2-(diphenylmethoxy)ethyl]-1-benzyl piperidine-based, dopamine transporter photoaffinity label. Life Sci 68:1839-49
Vaughan, R A; Gaffaney, J D; Lever, J R et al. (2001) Dual incorporation of photoaffinity ligands on dopamine transporters implicates proximity of labeled domains. Mol Pharmacol 59:1157-64
Dutta, A K; Reith, M E; Madras, B K (2001) Synthesis and preliminary characterization of a high-affinity novel radioligand for the dopamine transporter. Synapse 39:175-81
Dutta, A K; Xu, C; Reith, M E (1998) Tolerance in the replacement of the benzhydrylic O atom in 4-[2-(diphenylmethoxy)ethyl]-1-benzylpiperidine derivatives by an N atom: development of new-generation potent and selective N-analogue molecules for the dopamine transporter. J Med Chem 41:3293-7
Dutta, A K; Coffey, L L; Reith, M E (1998) Potent and selective ligands for the dopamine transporter (DAT): structure-activity relationship studies of novel 4-[2-(diphenylmethoxy)ethyl]-1-(3-phenylpropyl)piperidine analogues. J Med Chem 41:699-705
Dutta, A K; Coffey, L L; Reith, M E (1997) Highly selective, novel analogs of 4-[2-(diphenylmethoxy)ethyl]- 1-benzylpiperidine for the dopamine transporter: effect of different aromatic substitutions on their affinity and selectivity. J Med Chem 40:35-43
Dutta, A K; Xu, C; Reith, M E (1996) Structure-activity relationship studies of novel 4-[2-[bis(4-fluorophenyl)methoxy]ethyl]-1-(3-phenylpropyl)piperidine analogs: synthesis and biological evaluation at the dopamine and serotonin transporter sites. J Med Chem 39:749-56