Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
First Independent Research Support & Transition (FIRST) Awards (R29)
Project #
5R29DK045293-05
Application #
2016538
Study Section
Bacteriology and Mycology Subcommittee 2 (BM)
Project Start
1992-09-30
Project End
1997-09-29
Budget Start
1996-09-30
Budget End
1997-09-29
Support Year
5
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Vanderbilt University Medical Center
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
004413456
City
Nashville
State
TN
Country
United States
Zip Code
37212
Cao, P; Cover, T L (1997) High-level genetic diversity in the vapD chromosomal region of Helicobacter pylori. J Bacteriol 179:2852-6
Cover, T L; Hanson, P I; Heuser, J E (1997) Acid-induced dissociation of VacA, the Helicobacter pylori vacuolating cytotoxin, reveals its pattern of assembly. J Cell Biol 138:759-69
Eaton, K A; Cover, T L; Tummuru, M K et al. (1997) Role of vacuolating cytotoxin in gastritis due to Helicobacter pylori in gnotobiotic piglets. Infect Immun 65:3462-4
Atherton, J C; Peek Jr, R M; Tham, K T et al. (1997) Clinical and pathological importance of heterogeneity in vacA, the vacuolating cytotoxin gene of Helicobacter pylori. Gastroenterology 112:92-9
Ricci, V; Ciacci, C; Zarrilli, R et al. (1996) Effect of Helicobacter pylori on gastric epithelial cell migration and proliferation in vitro: role of VacA and CagA. Infect Immun 64:2829-33
Cover, T L (1996) The vacuolating cytotoxin of Helicobacter pylori. Mol Microbiol 20:241-6
Atherton, J C; Tham, K T; Peek Jr, R M et al. (1996) Density of Helicobacter pylori infection in vivo as assessed by quantitative culture and histology. J Infect Dis 174:552-6
Atherton, J C; Cao, P; Peek Jr, R M et al. (1995) Mosaicism in vacuolating cytotoxin alleles of Helicobacter pylori. Association of specific vacA types with cytotoxin production and peptic ulceration. J Biol Chem 270:17771-7
Blaser, M J; Perez-Perez, G I; Kleanthous, H et al. (1995) Infection with Helicobacter pylori strains possessing cagA is associated with an increased risk of developing adenocarcinoma of the stomach. Cancer Res 55:2111-5
Cover, T L; Glupczynski, Y; Lage, A P et al. (1995) Serologic detection of infection with cagA+ Helicobacter pylori strains. J Clin Microbiol 33:1496-500

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