Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
First Independent Research Support & Transition (FIRST) Awards (R29)
Project #
3R29ES005211-04S1
Application #
3465305
Study Section
Toxicology Subcommittee 2 (TOX)
Project Start
1989-07-01
Project End
1994-06-30
Budget Start
1992-07-01
Budget End
1993-06-30
Support Year
4
Fiscal Year
1993
Total Cost
Indirect Cost
Name
University of Pennsylvania
Department
Type
Schools of Medicine
DUNS #
042250712
City
Philadelphia
State
PA
Country
United States
Zip Code
19104
Mendelman, A; Zarchin, N; Rifkind, J et al. (2000) Brain multiparametric responses to carbon monoxide exposure in the aging rat. Brain Res 867:217-22
Meilin, S; Rogatsky, G G; Thom, S R et al. (1996) Effects of carbon monoxide on the brain may be mediated by nitric oxide. J Appl Physiol 81:1078-83
Mayevsky, A; Meilin, S; Rogatsky, G G et al. (1995) Multiparametric monitoring of the awake brain exposed to carbon monoxide. J Appl Physiol 78:1188-96
Hardy, K R; Thom, S R (1994) Pathophysiology and treatment of carbon monoxide poisoning. J Toxicol Clin Toxicol 32:613-29
Ischiropoulos, H; Mendiguren, I; Fisher, D et al. (1994) Role of neutrophils and nitric oxide in lung alveolar injury from smoke inhalation. Am J Respir Crit Care Med 150:337-41
Thom, S R; Mendiguren, I; Van Winkle, T et al. (1994) Smoke inhalation with a concurrent systemic stress results in lung alveolar injury. Am J Respir Crit Care Med 149:220-6
Thom, S R (1993) Leukocytes in carbon monoxide-mediated brain oxidative injury. Toxicol Appl Pharmacol 123:234-47
Thom, S R (1993) Functional inhibition of leukocyte B2 integrins by hyperbaric oxygen in carbon monoxide-mediated brain injury in rats. Toxicol Appl Pharmacol 123:248-56
Thom, S R (1992) Inert gas enhancement of superoxide radical production. Arch Biochem Biophys 295:391-6
Thom, S R (1992) Dehydrogenase conversion to oxidase and lipid peroxidation in brain after carbon monoxide poisoning. J Appl Physiol 73:1584-9